Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DME (ID: DEN0GVQ)

DME Name	Beta-HSD adrenal and gonadal type (HSD3B2) DME Info
Gene Name	HSD3B2

Molecule-Related Drug & Molecule List

Molecule-Related Drug List

Molecule Type:

DTT

DTP

DME

Drug Status:

Approved Drug(s)

Investigative Drug(s)

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4 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Norethindrone acetate	DMDGCQP	N. A.	N. A.	Approved	[1]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[2]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[3]
Pregnenolone	DM6VFO1	Schizophrenia	6A20	Phase 4	[4]
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1 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
17alpha-hydroxypregnenolone	DMT2EPG	Discovery agent	N.A.	Investigative	[4]
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Molecule Interaction Atlas

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References

1	Hormonal properties of norethisterone, 7alpha-methyl-norethisterone and their derivatives. J Steroid Biochem Mol Biol. 2000 Nov 15;74(4):213-22.
2	Selective inhibition of human 3beta-hydroxysteroid dehydrogenase type 1 as a potential treatment for breast cancer. J Steroid Biochem Mol Biol. 2011 May;125(1-2):57-65.
3	Tibolone: a unique version of hormone replacement therapy. Ann Pharmacother. 2004 May;38(5):874-81.
4	Structure/function relationships responsible for the kinetic differences between human type 1 and type 2 3beta-hydroxysteroid dehydrogenase and for the catalysis of the type 1 activity. J Biol Chem. 2002 Nov 8;277(45):42795-801.