Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DME (ID: DEP76YL)

• DME Name: Dimethylaniline oxidase 3 (FMO3) DME Info
• Gene Name: FMO3

Molecule-Related Drug & Molecule List

5 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Almotriptan malate	DMFG5ST	N. A.	N. A.	Approved	[1]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[2]
Ethionamide	DM8K3EI	Pulmonary tuberculosis	1B10.Z	Approved	[3]
Fedratinib hydrochloride	DML2DCR	N. A.	N. A.	Approved	[4]
Olopatadine	DMKMWQG	Allergic conjunctivitis	9A60.02	Approved	[]

2 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
HSR-803	DMAVIPZ	N. A.	N. A.	Phase 3	[5]
Itopride	DM7MLTR	N. A.	N. A.	Phase 3	[5]

References

• [1] Identification of the human liver enzymes involved in the metabolism of the antimigraine agent almotriptan. Drug Metab Dispos. 2003 Apr;31(4):404-11.
• [2] Identification of the human enzymes involved in the oxidative metabolism of dasatinib: an effective approach for determining metabolite formation kinetics. Drug Metab Dispos. 2008 Sep;36(9):1828-39.
• [3] Physiologically based pharmacokinetic modeling approach to predict drug-drug interactions with ethionamide involving impact of genetic polymorphism on FMO3. J Clin Pharmacol. 2019 Jun;59(6):880-889.
• [4] FDA label of Fedratinib. The 2020 official website of the U.S. Food and Drug Administration.
• [5] Development of a physiologically based pharmacokinetic model to predict the effects of flavin-containing monooxygenase 3 (FMO3) polymorphisms on itopride exposure. Biopharm Drug Dispos. 2017 Sep;38(6):389-393.