Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTP (ID: DT4YL5R)

DTP Name	Concentrative Na(+)-nucleoside cotransporter 3 (SLC28A3) DTP Info
UniProt ID	S28A3_HUMAN
Gene Name	CNT3

Molecule-Related Drug & Molecule List

Molecule-Related Drug List

Molecule Type:

DTT

DTP

DME

Drug Status:

Approved Drug(s)

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5 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clofarabine	DMCVJ86	Acute lymphoblastic leukaemia	2A85	Approved	[1]
Entecavir	DM7VTQO	Hepatitis B virus infection	1E51.0	Approved	[2]
Mercaptopurine	DMTM2IK	Acute lymphoblastic leukaemia	2A85	Approved	[3]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[4]
Thioguanine	DM7NKEV	Acute myeloid leukaemia	2A60	Approved	[3]
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Molecule Interaction Atlas

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References

1	Cytarabine-resistant leukemia cells are moderately sensitive to clofarabine in vitro. Anticancer Res. 2014 Apr;34(4):1657-62.
2	Multiple SLC and ABC Transporters Contribute to the Placental Transfer of Entecavir. Drug Metab Dispos. 2017 Mar;45(3):269-278.
3	Involvement of the concentrative nucleoside transporter 3 and equilibrative nucleoside transporter 2 in the resistance of T-lymphoblastic cell lines to thiopurines. Biochem Biophys Res Commun. 2006 Apr 28;343(1):208-15.
4	Kinetic study of anti-viral ribavirin uptake mediated by hCNT3 and hENT1 in Xenopus laevis oocytes. Biophys Chem. 2010 Mar;147(1-2):59-65.