General Information of DTT (ID: TT0I76D)

DTT Name Metabotropic glutamate receptor 7 (mGluR7) DTT Info
Gene Name GRM7

Molecule-Related Drug & Molecule List

Molecule-Related Drug List
Molecule Type:
DTT
DTP
DME
Drug Status:
Investigative Drug(s)
19 Investigative Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
(+)-MCPG DMG5QJB Discovery agent N.A. Investigative [1]
(1S,3R)-ACPD DM5DOAF Discovery agent N.A. Investigative [1]
ADX71743 DM3WAG6 Discovery agent N.A. Investigative [2]
alpha-methylserine-O-phosphate DMCIH1X Discovery agent N.A. Investigative [1]
AMN082 DMXDUCP Discovery agent N.A. Investigative [3]
L-AP4 DMPJFGI Discovery agent N.A. Investigative [1]
L-CCG-I DMPZ8XH Discovery agent N.A. Investigative [1]
L-serine-O-phosphate DMTJ1NH Discovery agent N.A. Investigative [1]
LSP1-2111 DM74J10 Discovery agent N.A. Investigative [4]
LSP4-2022 DMBWHGP Discovery agent N.A. Investigative [5]
MAP4 DMUCE93 Discovery agent N.A. Investigative [1]
MCCG DMKTX1A Discovery agent N.A. Investigative [1]
MMPIP DMWMZL7 Discovery agent N.A. Investigative [6]
MPPG DMJHQ9T Discovery agent N.A. Investigative [1]
MSOPPE DMU67CE Discovery agent N.A. Investigative [1]
PPG DM5IG4F Discovery agent N.A. Investigative [1]
XAP044 DMLTVI6 Discovery agent N.A. Investigative [7]
[3H]LY341495 DMGX0Y8 Discovery agent N.A. Investigative [1]
[3H]quisqualate DMDQBTX Discovery agent N.A. Investigative [8]
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⏷ Show the Full List of 19 Investigative Drug(s)
Molecule Interaction Atlas

References

1 Binding of [3H](2S,1'S,2'S)-2-(9-xanthylmethyl)-2-(2'-carboxycyclopropyl) glycine ([3H]LY341495) to cell membranes expressing recombinant human group III metabotropic glutamate receptor subtypes. Naunyn Schmiedebergs Arch Pharmacol. 2000 Dec;362(6):546-54.
2 ADX71743, a potent and selective negative allosteric modulator of metabotropic glutamate receptor 7: in vitro and in vivo characterization. J Pharmacol Exp Ther. 2013 Mar;344(3):624-36.
3 A selective metabotropic glutamate receptor 7 agonist: activation of receptor signaling via an allosteric site modulates stress parameters in vivo. Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18712-7.
4 Electrophysiological and behavioral evidence that modulation of metabotropic glutamate receptor 4 with a new agonist reverses experimental parkinsonism. FASEB J. 2009 Oct;23(10):3619-28.
5 A novel selective metabotropic glutamate receptor 4 agonist reveals new possibilities for developing subtype selective ligands with therapeutic potential. FASEB J. 2012 Apr;26(4):1682-93.
6 Context-dependent pharmacology exhibited by negative allosteric modulators of metabotropic glutamate receptor 7. Mol Pharmacol. 2010 Mar;77(3):459-68.
7 Blocking metabotropic glutamate receptor subtype 7 (mGlu7) via the Venus flytrap domain (VFTD) inhibits amygdala plasticity, stress, and anxiety-related behavior. J Biol Chem. 2014 Apr 18;289(16):10975-87.
8 Excitatory amino acid receptor ligands: resolution, absolute stereochemistry, and enantiopharmacology of 2-amino-3-(4-butyl-3-hydroxyisoxazol-5-yl)... J Med Chem. 1998 Mar 12;41(6):930-9.