Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TT0OFWN)

• DTT Name: Pseudomonas UDP-3-O-acyl-GlcNAc deacetylase (Pseudo lpxC) DTT Info
• Gene Name: Pseudo lpxC

Molecule-Related Drug & Molecule List

1 Preclinical Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
LpxC-1	DMV1A25	Acinetobacter baumannii infection	CA40.0Y	Preclinical	[1]

1 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
RC-01	DM4FNWO	Gram-negative bacterial infection	1B74-1G40	Terminated	[2]

7 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
3-(heptyloxy)benzoic acid	DMQZU9G	Discovery agent	N.A.	Investigative	[3]
BB-78484	DMFBN9O	Discovery agent	N.A.	Investigative	[4]
BB-78485	DMJKA3F	Discovery agent	N.A.	Investigative	[4]
Cacodylate Ion	DMK4XLD	Discovery agent	N.A.	Investigative	[5]
MYRISTIC ACID	DMYX0BL	Discovery agent	N.A.	Investigative	[3]
Palmitoleic Acid	DM4W5X8	Discovery agent	N.A.	Investigative	[5]
Tu-514	DMUR0TF	Discovery agent	N.A.	Investigative	[5]

References

• [1] Different drugs for bad bugs: antivirulence strategies in the age of antibiotic resistance. Nat Rev Drug Discov. 2017 Jul;16(7):457-471.
• [2] The global preclinical antibacterial pipeline. Nat Rev Microbiol. 2020 May;18(5):275-285.
• [3] The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
• [4] Antibacterial activities and characterization of novel inhibitors of LpxC. Antimicrob Agents Chemother. 2002 Jun;46(6):1793-9.
• [5] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.