Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TT2O4W9)

• DTT Name: Luteinizing hormone receptor (LHCGR) DTT Info
• Gene Name: LHCGR

Molecule-Related Drug & Molecule List

3 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Choriogonadotropin alfa	DMFMZ3G	Female infertility	GA31.Z	Approved	[1]
Chorionic Gonadotropin	DMFT73E	Fertility disorders	5A61	Approved	[1]
Lutropin alfa	DM7K5GD	Female infertility	GA31.Z	Approved	[2]

2 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ML-04	DMQSO4L	Myelodysplastic syndrome	2A37	Phase 2	[3]
Org-43902	DME0WX2	Infertility	GB04	Phase 1	[4]

2 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
LDI-200	DMKMTR7	leukaemia	2A60-2B33	Discontinued in Phase 3	[5]
Human chorionic gonadotropin	DMA7EFM	Heart disease	BA41-BA42	Terminated	[5]

1 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
EP-200	DMAURX5	Solid tumour/cancer	2A00-2F9Z	Investigative	[5]

References

• [1] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
• [2] Lutropin alfa. Drugs. 2008;68(11):1529-40.
• [3] Evaluation of radiolabeled ML04, a putative irreversible inhibitor of epidermal growth factor receptor, as a bioprobe for PET imaging of EGFR-overexpressing tumors. Nucl Med Biol. 2007 Jan;34(1):55-70.
• [4] First evidence of ovulation induced by oral LH agonists in healthy female volunteers of reproductive age. J Clin Endocrinol Metab. 2013 Apr;98(4):1558-66.
• [5] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 254).