General Information of DTT (ID: TT2O84V)

DTT Name Thromboxane A2 receptor (TBXA2R) DTT Info
Gene Name TBXA2R

Molecule-Related Drug & Molecule List

Molecule-Related Drug List
Molecule Type:
DTT
DTP
DME
Drug Status:
Discontinued Drug(s)
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
3 Approved Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
Alprostadil DMWH7NQ Aorta coarctation Approved [1]
Ridogrel DMWH9CN Acute myocardial infarction BA41 Approved [2]
LAROPIPRANT DM5FABJ Coronary heart disease BA80.Z Phase 4 [3]
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11 Clinical Trial Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ramatroban DMB8UQ3 Perennial allergic rhinitis CA08.03 Phase 2/3 [4]
FK-070 DMJSD5W Angina pectoris BA40 Phase 2 [5]
Ifetroban DMEV39E Aspirin-induced asthma CA23.20 Phase 2 [6]
Ifetroban sodium DMZP84Y Thrombosis DB61-GB90 Phase 2 [7]
KP-496 DMCO8UZ Asthma CA23 Phase 2 [8]
TAK-128 DMHPEFS Diabetic neuropathy 8C0Z Phase 2 [9]
BIBV 308 DMUBMN5 Peripheral vascular disease BD4Z Phase 1 [7]
DT-TX-30 DM1FX09 Angina pectoris BA40 Phase 1 [10]
G-619 DM3H6YC Thrombosis DB61-GB90 Phase 1 [11]
YM-57158 DMS31YW Allergic rhinitis CA08.0 Phase 1 [12]
PGF2alpha DM4XAU7 Solid tumour/cancer 2A00-2F9Z Clinical trial [13]
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⏷ Show the Full List of 11 Clinical Trial Drug(s)
18 Discontinued Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
Domitroban DM3OUWC Thrombosis DB61-GB90 Discontinued in Preregistration [14]
DALTROBAN DMNQIKV N. A. N. A. Discontinued in Phase 3 [15]
Seratrodast DMPNTDL Allergic asthma CA23.0 Discontinued in Phase 3 [16]
Terutroban sodium DMYF1DN Thrombosis DB61-GB90 Discontinued in Phase 3 [17]
ICI-192605 DMY8X6Q Thrombosis DB61-GB90 Discontinued in Phase 2 [18]
Linotroban DM32JL5 Thrombosis DB61-GB90 Discontinued in Phase 2 [19]
SQ-30741 DMTC4VY Thrombosis DB61-GB90 Discontinued in Phase 2 [20]
Z-335 DM2438J Thrombosis DB61-GB90 Discontinued in Phase 2 [21]
CGS-22652 DMF05DL Angina pectoris BA40 Discontinued in Phase 1 [22]
KT2-962 DMBH5G3 Thrombosis DB61-GB90 Discontinued in Phase 1 [23]
KW-3635 DMG068H Thrombosis DB61-GB90 Discontinued in Phase 1 [24]
L-657925 DMOTY3G N. A. N. A. Terminated [25]
ON-579 DMTS6HB Asthma CA23 Terminated [26]
SQ-33961 DMZBQ4I Thrombosis DB61-GB90 Terminated [27]
Sulotroban DM4SVIR Asthma CA23 Terminated [28]
UP-116-77 DMEIR7F Thrombosis DB61-GB90 Terminated [29]
Vapiprost DMJLV03 Cardiovascular disease BA00-BE2Z Terminated [30]
ZT-386 DM193WR Asthma CA23 Terminated [31]
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⏷ Show the Full List of 18 Discontinued Drug(s)
27 Investigative Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
10,10-difluoro TXA2 DML745Y Discovery agent N.A. Investigative [32]
AGN 191976 DMTPV4Y Discovery agent N.A. Investigative [33]
AGN192093 DMISJXB Discovery agent N.A. Investigative [33]
AH23848 DM4S1Y6 Discovery agent N.A. Investigative [13]
BM-573 DMD2H7L Discovery agent N.A. Investigative [34]
butaprost (free acid form) DM5MZHP Discovery agent N.A. Investigative [13]
carbacyclin DMMBQYE Discovery agent N.A. Investigative [13]
carbocyclic thromboxane A2 DMGKSVF Discovery agent N.A. Investigative [35]
cloprostenol DMH01JV Discovery agent N.A. Investigative [13]
EP 171 DM7YION Discovery agent N.A. Investigative [36]
fluprostenol DM9Q2PG Discovery agent N.A. Investigative [13]
I-BOP DMJAPML Discovery agent N.A. Investigative [37]
I-SAP DMJ2FQA Discovery agent N.A. Investigative [38]
M&B 28767 DMJQG82 Discovery agent N.A. Investigative [13]
ONO-3708 DM84IW9 Discovery agent N.A. Investigative [39]
ONO-8809 DM5BMA9 Thrombosis DB61-GB90 Investigative [40]
PGH2 DMZFVGC Discovery agent N.A. Investigative [35]
S 18204 DM2FC5V Discovery agent N.A. Investigative [41]
SQ 26655 DMRP42B Discovery agent N.A. Investigative [42]
SQ-29548 DM9G3UD Discovery agent N.A. Investigative [13]
STA2 DMIYJ2M Discovery agent N.A. Investigative [37]
U-44069 DM0DMNS Discovery agent N.A. Investigative [43]
U46619 DM13FX4 Discovery agent N.A. Investigative [13]
[125I]BOP DMV6I7H Discovery agent N.A. Investigative [44]
[125I]PTA-OH DMROKJP Discovery agent N.A. Investigative [45]
[125I]SAP DM1DXHG Discovery agent N.A. Investigative [38]
[125I]SQ-29548 DM0GKMA Discovery agent N.A. Investigative [46]
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⏷ Show the Full List of 27 Investigative Drug(s)
Molecule Interaction Atlas

References

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11 G 619, a dual thromboxane synthase inhibitor and thromboxane A2 receptor antagonist, inhibits tumor necrosis factor-alpha biosynthesis. Eur J Pharmacol. 1995 Nov 3;286(1):31-9.
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20 Influence of SQ 30741 on thromboxane receptor-mediated responses in the feline pulmonary vascular bed. J Appl Physiol (1985). 1991 Nov;71(5):2012-8.
21 Pharmacokinetic and pharmacodynamic properties of a new thromboxane receptor antagonist (Z-335) after single and multiple oral administrations to healthy volunteers. J Clin Pharmacol. 2002 Jul;42(7):782-90.
22 Blood pressure effects of thromboxane A2 blockade in spontaneously hypertensive rats. Clin Exp Pharmacol Physiol. 1993 Nov;20(11):679-87.
23 Azulene derivatives as TXA2/PGH2 receptor antagonists--II. Synthesis and biological activity of 6-mono- and 6-dihydroxylated-isopropylazulenes. Bioorg Med Chem. 1996 Apr;4(4):575-91.
24 Antithrombotic effects of KW-3635, a thromboxane A2-receptor antagonist, in guinea pigs. Jpn J Pharmacol. 1994 Jun;65(2):93-8.
25 Novel synthesis and biochemical properties of an [125I]-labeled photoaffinity probe for thromboxane A2/prostaglandin H2 receptors. J Med Chem. 1991 Apr;34(4):1511-4.
26 The effect of a TXA2 receptor antagonist ON-579 on experimental allergic reactions. Prostaglandins Leukot Essent Fatty Acids. 1995 Aug;53(2):123-33.
27 Conformationally-restricted analogs of TXA2 antagonist SQ 33,961: Receptor binding conformation of the carboxyl sidechain. Bioorganic & Medicinal Chemistry Letters Volume 1, Issue 9, 1991, Pages 465-470.
28 The PGI2-analogue iloprost and the TXA2-receptor antagonist sulotroban synergistically inhibit TXA2-dependent platelet activation. Prostaglandins. 1988 Dec;36(6):751-60.
29 Synthesis and structure-activity relationships of novel benzimidazole and imidazo[4,5-b]pyridine acid derivatives as thromboxane A2 receptor antagonists. J Med Chem. 1993 Apr 30;36(9):1175-87.
30 Effects of vapiprost, a novel thromboxane receptor antagonist, on thrombus formation and vascular patency after thrombolysis by tissue-type plasminogen activator.. Br J Pharmacol. 1992 July; 106(3): 533-538.
31 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004057)
32 Difluorothromboxane A2 and stereoisomers: stable derivatives of thromboxane A2 with differential effects on platelets and blood vessels. Proc Natl Acad Sci U S A. 1989 Jul;86(14):5600-4.
33 Evidence for human thromboxane receptor heterogeneity using a novel series of 9,11-cyclic carbonate derivatives of prostaglandin F2 alpha. Br J Pharmacol. 1996 Mar;117(6):1171-80.
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37 Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. Br J Pharmacol. 1997 Sep;122(2):217-24.
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39 Characterization of U46619 binding in unactivated, intact human platelets and determination of binding site affinities of four TXA2/PGH2 receptor antagonists (13-APA, BM 13.177, ONO 3708 and SQ 29,548). Thromb Res. 1986 Feb 15;41(4):471-81.
40 Anti-thrombotic effect of ONO-8809, a novel TXA2/PG endoperoxide receptor antagonist. Adv Prostaglandin Thromboxane Leukot Res. 1991;21B:599-602.
41 Antithrombotic effects of S 18886, a novel orally active thromboxane A2 receptor antagonist. J Thromb Haemost. 2004 Mar;2(3):492-8.
42 Synthesis and in vitro pharmacology of 7-oxabicyclo[2.2.1]heptane analogues of thromboxane A2/PGH2. J Med Chem. 1985 Nov;28(11):1580-90.
43 cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain... J Med Chem. 2008 Nov 27;51(22):7094-8.
44 Characterization of an 125I-labeled thromboxane A2/prostaglandin H2 receptor agonist. J Pharmacol Exp Ther. 1989 Nov;251(2):557-62.
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46 Characterization of [5,6-3H]SQ 29,548 as a high affinity radioligand, binding to thromboxane A2/prostaglandin H2-receptors in human platelets. J Pharmacol Exp Ther. 1988 Jun;245(3):786-92.