Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TT3CPZW)

• DTT Name: Human papillomavirus protein E7 (HPV E7) DTT Info
• Gene Name: HPV E7

Molecule-Related Drug & Molecule List

5 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
VGX-3100	DMMQ2U9	Cervical Intraepithelial neoplasia	2E66.1	Phase 3	[1]
ADXS-HPV	DMC8NAO	Cervical cancer	2C77.0	Phase 2	[2]
Tipapkinogene sovacivec	DM5XRMA	Cervical Intraepithelial neoplasia	2E66.1	Phase 2	[3]
CIGB-228	DMJFPK6	Human papillomavirus infection	1A9Y	Phase 1	[4]
KITE-439	DMUB3H9	Cervical cancer	2C77.0	Phase 1	[5]

References

• [1] Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
• [2] ADXS11-001 immunotherapy targeting HPV-E7: updated survival and safety data from a phase 2 study in Indian women with recurrent/refractory cervical cancer. Journal for ImmunoTherapy of Cancer, 2013, 1(Suppl 1):P231.
• [3] Immune therapy for human papillomaviruses-related cancers
• [4] Safety and Immunogenicity of a Human Papillomavirus Peptide Vaccine (CIGB-228) in Women with High-Grade Cervical Intraepithelial Neoplasia: First-in-Human, Proof-of-Concept Trial. ISRN Obstet Gynecol. 2011; 2011: 292951.
• [5] ClinicalTrials.gov (NCT03912831) Safety and Efficacy of KITE-439 in HLA-A*02:01+ Adults With Relapsed/Refractory HPV16+ Cancers. U.S. National Institutes of Health.