Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TT42OGM)

• DTT Name: Hematopoietic cell kinase (HCK) DTT Info
• UniProt ID: HCK_HUMAN
• Gene Name: HCK

Molecule-Related Drug & Molecule List

9 Patented Agent(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
3-(6-allyloxy-2-naphthyl)-1-(4-piperidylmethyl)pyrazolo[3,4-d]pyrimidin-4-amine	DM0DYAU	N. A.	N. A.	Patented	[1]
BK3	DM6YQO3	N. A.	N. A.	Patented	[1]
BK7	DMQD4X2	N. A.	N. A.	Patented	[1]
Doramapimod	DM6BU7N	Inflammatory bowel disease	DD72	Patented	[2]
SB19065	DM2MQD0	N. A.	N. A.	Patented	[3]
Unii-I92MU0V408	DMUD7H8	N. A.	N. A.	Patented	[2]
US8933228, 3	DMPNCOL	N. A.	N. A.	Patented	[2]
US8933228, Ref 2	DMKEX51	N. A.	N. A.	Patented	[4]
US9108950, 1	DMPT2ZS	N. A.	N. A.	Patented	[5]

2 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PMID15546730C2	DMOPUIH	Discovery agent	N.A.	Investigative	[6]
PP121	DMU8KTO	Discovery agent	N.A.	Investigative	[7]

References

• [1] Compositions and methods for treating toxoplasmosis, cryptosporidiosis, and other apicomplexan protozoan related diseases. US9765037.
• [2] Respiratory formulations and compounds for use therein. US8933228.
• [3] Anti-inflammatory compound having inhibitory activity against multiple tyrosine kinases and pharmaceutical composition containing same. US9062066.
• [4] 1-pyrazolyl-3-(4-((2-anilinopyrimidin-4-yl)oxy)napththalen-1-yl) ureas as P38 MAP knase inhibitors. US9724347.
• [5] 1-pyrazolyl-3-(4-((2-anilinopyrimidin-4-yl)oxy)napththalen-1-yl) ureas as p38 MAP kinase inhibitors. US9108950.
• [6] Discovery of novel 2-(aminoheteroaryl)-thiazole-5-carboxamides as potent and orally active Src-family kinase p56(Lck) inhibitors. Bioorg Med Chem Lett. 2004 Dec 20;14(24):6061-6.
• [7] Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases. Nat Chem Biol. 2008 Nov;4(11):691-9.