Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TT48WR6)

• DTT Name: Integrin alpha-L (ITGAL) DTT Info
• Gene Name: ITGAL

Molecule-Related Drug & Molecule List

2 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Efalizumab	DMCKL5V	Psoriasis vulgaris	EA90	Approved	[1]
lifitegrast	DM4WVC5	Dry eye disease	9E1Z	Approved	[2]

2 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BMS-587101	DMS2IC9	Psoriasis vulgaris	EA90	Discontinued in Phase 2	[3]
IC-747	DM1LVRP	Psoriasis vulgaris	EA90	Discontinued in Phase 2	[4]

1 Preclinical Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cytolin	DMV8APG	Human immunodeficiency virus infection	1C62	Preclinical	[5]

3 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
A-286982	DM98VFW	Discovery agent	N.A.	Investigative	[6]
Leukotoxin	DMYX2NJ	Autoimmune diabetes	5A10	Investigative	[7]
LFA703	DM5G307	Discovery agent	N.A.	Investigative	[8]

References

• [1] [Successful therapy of discoid lupus erythematosus with efalizumab]. Hautarzt. 2010 Mar;61(3):246-9.
• [2] Corneal inflammation is inhibited by the LFA-1 antagonist, lifitegrast (SAR 1118). J Ocul Pharmacol Ther. 2013 May;29(4):395-402.
• [3] Small molecule antagonist of leukocyte function associated antigen-1 (LFA-1): structure-activity relationships leading to the identification of 6-(... J Med Chem. 2010 May 13;53(9):3814-30.
• [4] HECA-452+ T Cells Migrate Through Superficial Vascular Plexus but Not Through Deep Vascular Plexus Endothelium. Journal of Investigative Dermatology. 04/1997; 108(3):343-8.
• [5] Cytokine-induced phagocyte adhesion to human mesangial cells: role of CD11/CD18 integrins and ICAM-1. Am J Physiol. 1991 Dec;261(6 Pt 2):F1071-9.
• [6] Discovery of tetrahydroisoquinoline (THIQ) derivatives as potent and orally bioavailable LFA-1/ICAM-1 antagonists. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5269-73.
• [7] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2451).
• [8] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.