General Information of DTT (ID: TT57ID8)

DTT Name Respiratory syncytial virus protein F (RSV F) DTT Info
Gene Name RSV F

Molecule-Related Drug & Molecule List

Molecule-Related Drug List
Molecule Type:
DTT
DTP
DME
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Preclinical Drug(s)
Discontinued Drug(s)
2 Approved Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lasofoxifene DMHA18P Osteoporosis FB83.0 Approved [1]
Palivizumab DMQM9S0 Respiratory syncytial virus infection 1C80 Approved [2]
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7 Clinical Trial Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
Motavizumab DMB24H7 Respiratory syncytial virus infection 1C80 Phase 3 [3]
SAR438584 DMDMAE4 Respiratory syncytial virus infection 1C80 Phase 3 [4]
MK-1654 DM2YNMI Respiratory syncytial virus infection 1C80 Phase 2/3 [5]
GS-5806 DMDAHL6 Respiratory syncytial virus infection 1C80 Phase 2 [6]
JNJ-53718678 DMJ1FXL Respiratory syncytial virus infection 1C80 Phase 2 [7]
RV521 DMSW5XJ Respiratory syncytial virus infection 1C80 Phase 2 [8]
MEDI-557 DM6ADMG Respiratory syncytial virus infection 1C80 Phase 1 [3]
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⏷ Show the Full List of 7 Clinical Trial Drug(s)
1 Preclinical Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
TMC-353121 DMDSJO8 Respiratory syncytial virus infection 1C80 Preclinical [1]
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1 Discontinued Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
CL-387626 DMA4DNX Virus infection 1A24-1D9Z Terminated [9]
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Molecule Interaction Atlas

References

1 Prospects for the development of fusion inhibitors to treat human respiratory syncytial virus infection. Curr Opin Drug Discov Devel. 2009 Jul;12(4):479-87.
2 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
3 Motavizumab. Correction in: MAbs. 2010 Sep-Oct; 2(5): 591.
4 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800040470)
5 A potent broadly neutralizing human RSV antibody targets conserved site IV of the fusion glycoprotein. Nat Commun. 2019 Sep 12;10(1):4153.
6 Discovery of an oral respiratory syncytial virus (RSV) fusion inhibitor (GS-5806) and clinical proof of concept in a human RSV challenge study. J Med Chem. 2015 Feb 26;58(4):1630-43.
7 Antiviral Activity of Oral JNJ-53718678 in Healthy Adult Volunteers Challenged With Respiratory Syncytial Virus: A Placebo-Controlled Study. J Infect Dis. 2018 Jul 24;218(5):748-756.
8 Discovery of Sisunatovir (RV521), an Inhibitor of Respiratory Syncytial Virus Fusion. J Med Chem. 2021 Apr 8;64(7):3658-3676.
9 Respiratory Syncytial Virus Entry Inhibitors Targeting the F Protein. Viruses. 2013 January; 5(1): 211-225.