Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TT57ID8)

• DTT Name: Respiratory syncytial virus protein F (RSV F) DTT Info
• UniProt ID: FUS_HRSVA
• Gene Name: RSV F

Molecule-Related Drug & Molecule List

2 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lasofoxifene	DMHA18P	Osteoporosis	FB83.0	Approved	[1]
Palivizumab	DMQM9S0	Respiratory syncytial virus infection	1C80	Approved	[2]

7 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Motavizumab	DMB24H7	Respiratory syncytial virus infection	1C80	Phase 3	[3]
SAR438584	DMDMAE4	Respiratory syncytial virus infection	1C80	Phase 3	[4]
MK-1654	DM2YNMI	Respiratory syncytial virus infection	1C80	Phase 2/3	[5]
GS-5806	DMDAHL6	Respiratory syncytial virus infection	1C80	Phase 2	[6]
JNJ-53718678	DMJ1FXL	Respiratory syncytial virus infection	1C80	Phase 2	[7]
RV521	DMSW5XJ	Respiratory syncytial virus infection	1C80	Phase 2	[8]
MEDI-557	DM6ADMG	Respiratory syncytial virus infection	1C80	Phase 1	[3]

1 Preclinical Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
TMC-353121	DMDSJO8	Respiratory syncytial virus infection	1C80	Preclinical	[1]

1 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
CL-387626	DMA4DNX	Virus infection	1A24-1D9Z	Terminated	[9]

References

• [1] Prospects for the development of fusion inhibitors to treat human respiratory syncytial virus infection. Curr Opin Drug Discov Devel. 2009 Jul;12(4):479-87.
• [2] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
• [3] Motavizumab. Correction in: MAbs. 2010 Sep-Oct; 2(5): 591.
• [4] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800040470)
• [5] A potent broadly neutralizing human RSV antibody targets conserved site IV of the fusion glycoprotein. Nat Commun. 2019 Sep 12;10(1):4153.
• [6] Discovery of an oral respiratory syncytial virus (RSV) fusion inhibitor (GS-5806) and clinical proof of concept in a human RSV challenge study. J Med Chem. 2015 Feb 26;58(4):1630-43.
• [7] Antiviral Activity of Oral JNJ-53718678 in Healthy Adult Volunteers Challenged With Respiratory Syncytial Virus: A Placebo-Controlled Study. J Infect Dis. 2018 Jul 24;218(5):748-756.
• [8] Discovery of Sisunatovir (RV521), an Inhibitor of Respiratory Syncytial Virus Fusion. J Med Chem. 2021 Apr 8;64(7):3658-3676.
• [9] Respiratory Syncytial Virus Entry Inhibitors Targeting the F Protein. Viruses. 2013 January; 5(1): 211-225.