Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TT5TKPM)

• DTT Name: Neutral endopeptidase (MME) DTT Info
• Gene Name: MME

Molecule-Related Drug & Molecule List

1 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
LCZ696	DMLFX7K	Heart failure	BD10-BD13	Approved	[1]

13 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Candoxatril	DMHJCGV	Hypertension	BA00-BA04	Phase 3	[2]
Gallopamil	DMXBR27	Asthma	CA23	Phase 2	[3]
Sampatrilat	DMXTOVE	Hypotension	BA20-BA21	Phase 2	[4]
SLV 306	DMCDON3	Acute decompensated heart failure	BD1Z	Phase 2	[5]
SLV-334	DMXCJKY	Brain injury	NA07.Z	Phase 2	[6]
VX-15	DMLWM4G	Huntington disease	8A01.10	Phase 2	[7]
CART-10 cells	DMQ4UJ6	Acute lymphoblastic leukaemia	2A85	Phase 1	[8]
CD10-CART	DM0XDYT	leukaemia	2A60-2B33	Phase 1	[9]
Debio 0827	DMQIEFB	Chronic pain	MG30	Phase 1	[10]
GW-796406	DMQ46DN	Hypotension	BA20-BA21	Phase 1	[3]
Pfizer 4	DMME5P8	Female sexual arousal dysfunction	HA01.1	Phase 1	[11]
SLV-338	DM7WKTM	Cardiovascular disease	BA00-BE2Z	Phase 1	[12]
TD-0714	DMO8L6T	Heart failure	BD10-BD13	Phase 1	[13]

18 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ilepatril	DMTR50E	Diabetic nephropathy	GB61.Z	Discontinued in Phase 2/3	[14]
CGS-25462	DM2OWCV	Hypertension	BA00-BA04	Discontinued in Phase 2	[15]
Fasidotril	DMRU1KT	Hypotension	BA20-BA21	Discontinued in Phase 2	[16]
Gemopatrilat	DMLMT5O	Hypotension	BA20-BA21	Discontinued in Phase 2	[17]
M-100240	DMQ1LWU	Hypotension	BA20-BA21	Discontinued in Phase 2	[18]
SCH-32615	DMAGBM2	Pain	MG30-MG3Z	Discontinued in Phase 2	[19]
Sch-34826	DMZR6GI	Hypertension	BA00-BA04	Discontinued in Phase 2	[20]
SCH-42495	DM2RH51	Hypotension	BA20-BA21	Discontinued in Phase 2	[21]
Candoxatrilat	DMQIWZL	Heart failure	BD10-BD13	Discontinued in Phase 1	[22]
BMS-182657	DM0K4DZ	Cardiovascular disease	BA00-BE2Z	Terminated	[23]
CGS-26303	DMFZM09	N. A.	N. A.	Terminated	[24]
CGS-26393	DM4U72A	Heart disease	BA41-BA42	Terminated	[25]
CGS-30440	DM94WIO	Hypertension	BA00-BA04	Terminated	[26]
GW-660511	DMG5A1Z	Hypertension	BA00-BA04	Terminated	[27]
Omapatrilat	DMAGUY0	Hypertension	BA00-BA04	Terminated	[28]
SCH-54470	DMEWLZ7	N. A.	N. A.	Terminated	[29]
SQ-26332	DM6SW2R	N. A.	N. A.	Terminated	[30]
SQ-28603	DM9DJFS	Hypertension	BA00-BA04	Terminated	[31]

9 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
9-Mercaptomethyl-10-oxo-azecane-2-carboxylic acid	DMM2GQC	Discovery agent	N.A.	Investigative	[32]
CGS-314447	DM514L0	Discovery agent	N.A.	Investigative	[24]
fasidotrilat	DMC8G7X	Discovery agent	N.A.	Investigative	[33]
LBQ657	DMQ2DFN	Discovery agent	N.A.	Investigative	[34]
Phosphoramidon	DM3VL7G	Discovery agent	N.A.	Investigative	[35]
PMID18078750C1b	DMO21H5	Discovery agent	N.A.	Investigative	[36]
RB-105	DMRK3HO	Hypertension	BA00-BA04	Investigative	[37]
Thiorphan	DM86LFB	Discovery agent	N.A.	Investigative	[38]
[2(R,S)-2-Sulfanylheptanoyl]-Phe-Ala	DMI9RLZ	Discovery agent	N.A.	Investigative	[39]

References

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• [8] ClinicalTrials.gov (NCT03291444) CAR-T Cells Combined With Peptide Specific Dendritic Cell in Relapsed/Refractory Leukemia/MDS
• [9] ClinicalTrials.gov (NCT03407859) Sequential Treatment With CD20/CD22/CD10-CART After CD19-CART Treatment Base on MRD in Relapsed/Refractory B-ALL
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• [11] Designing drugs for the treatment of female sexual dysfunction. Drug Discov Today. 2007 Sep;12(17-18):757-66.
• [12] Renoprotective effects of combined endothelin-converting enzyme/neutral endopeptidase inhibitor SLV338 in acute and chronic experimental renal damage. Clin Lab. 2011;57(7-8):507-15.
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• [15] Quantitative analytical methods for the determination of a new hypertension drug, CGS 25462, and its metabolites (CGS 25659 and CGS 24592) in human plasma by high-performance liquid chromatography. JChromatogr B Biomed Sci Appl. 1998 Mar 20;706(2):287-94.
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• [19] The antinociceptive effects of SCH-32615, a neutral endopeptidase (enkephalinase) inhibitor, microinjected into the periaqueductal, ventral medulla and amygdala. Brain Res. 1990 Jun 18;520(1-2):123-30.
• [20] Pharmacology of SCH 34826, an orally active enkephalinase inhibitor analgesic. J Pharmacol Exp Ther. 1988 Jun;245(3):829-38.
• [21] Endopeptidase 24.11 inhibition by SCH 42495 in essential hypertension. Hypertension. 1993 Jul;22(1):119-26.
• [22] Candoxatril, an orally active neutral endopeptidase inhibitor, raises plasma atrial natriuretic factor and is natriuretic in essential hypertension. J Hypertens. 1992 Mar;10(3):271-7.
• [23] Cardiovascular effects of the novel dual inhibitor of neutral endopeptidase and angiotensin-converting enzyme BMS-182657 in experimental hypertension and heart failure. J Pharmacol Exp Ther. 1995 Nov;275(2):745-52.
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• [31] Evaluation of SQ 28,603, an inhibitor of neutral endopeptidase, in conscious monkeys. Can J Physiol Pharmacol. 1991 Oct;69(10):1609-17.
• [32] Design and synthesis of an orally active macrocyclic neutral endopeptidase 24.11 inhibitor. J Med Chem. 1993 Nov 26;36(24):3821-8.
• [33] Modelling of aldose reductase inhibitory activity of pyrrol-1-yl-acetic acid derivatives by means of multivariate statistics. Med Chem. 2005 Jul;1(4):321-6.
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