Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TT5ZWB6)

• DTT Name: Dihydrodiol dehydrogenase type I (AKR1C3) DTT Info
• Gene Name: AKR1C3

Molecule-Related Drug & Molecule List

1 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flufenamic Acid	DMC8VNH	Dysmenorrhea	GA34.3	Approved	[1]

1 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ASP-9521	DM8V0UL	Prostate cancer	2C82.0	Phase 1/2	[2]

13 Patented Agent(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-naphthylacetic acids derivative 1	DM5KTDY	N. A.	N. A.	Patented	[3]
Indomethacin analog 1	DM3E5V6	N. A.	N. A.	Patented	[3]
Indomethacin analog 2	DMKFPJ7	N. A.	N. A.	Patented	[3]
Indomethacin analog 3	DM53JXE	N. A.	N. A.	Patented	[3]
Isoquinolone derivative 1	DMW6R0H	N. A.	N. A.	Patented	[3]
N-(benzimidazole/indole) benzoic acid derivative 1	DMGQWKH	N. A.	N. A.	Patented	[3]
N-(benzimidazole/indole) benzoic acid derivative 2	DMOPUFM	N. A.	N. A.	Patented	[3]
N-(benzimidazolylcarbonyl)-piperidine derivative 1	DM541QW	N. A.	N. A.	Patented	[3]
N-(indolylcarbonyl)-piperidine derivative 1	DMARHJ9	N. A.	N. A.	Patented	[3]
N-(naphthylamino)-benzoate derivative 1	DM310ES	N. A.	N. A.	Patented	[3]
N-(phenylamino)-benzoate derivative 1	DMNIWVG	N. A.	N. A.	Patented	[3]
N-(pyridinepyrroylylcarbonyl)-piperidine derivative 1	DMA85UD	N. A.	N. A.	Patented	[3]
Nitrogen/sulfur-substituted estrene derivative 1	DMD7OW0	N. A.	N. A.	Patented	[3]

15 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2'-Monophosphoadenosine 5'-Diphosphoribose	DME9S8M	Discovery agent	N.A.	Investigative	[4]
2,2-Dibenzylcyclopentanol	DMFPYU8	Discovery agent	N.A.	Investigative	[5]
2-(4-Chlorobenzylidene)cyclopentanone	DMOH2YC	Discovery agent	N.A.	Investigative	[5]
2-(4-chlorobenzylidene)cyclopentyl ethyl ether	DMFE93N	Discovery agent	N.A.	Investigative	[5]
2-(4-chlorobenzylidene)cyclopentylmethyl ether	DMTW9B7	Discovery agent	N.A.	Investigative	[5]
2-Methyl-2,4-Pentanediol	DMD45CU	Discovery agent	N.A.	Investigative	[4]
2-[(2,2-diphenylacetyl)amino]benzoic acid	DMVSTG7	Discovery agent	N.A.	Investigative	[6]
3-Bromo-5-phenylsalicylc acid	DMZTDCL	Discovery agent	N.A.	Investigative	[7]
3-Phenylcyclopentanecarboxylic acid	DMJOD1T	Discovery agent	N.A.	Investigative	[5]
4-ANDROSTENE-3-17-DIONE	DMSE8NU	Discovery agent	N.A.	Investigative	[4]
Acetate Ion	DMD08RH	Discovery agent	N.A.	Investigative	[4]
EM-1424	DMSLHDN	Discovery agent	N.A.	Investigative	[8]
EM1396	DMZ2EL1	Discovery agent	N.A.	Investigative	[8]
M-Phenoxybenzoic Acid For Cis-Isomer	DMJRK47	Discovery agent	N.A.	Investigative	[6]
Rutin	DMEHRAJ	Discovery agent	N.A.	Investigative	[4]

References

• [1] Ouellet M, Percival MD: Effect of inhibitor time-dependency on selectivity towards cyclooxygenase isoforms. Biochem J. 1995 Feb 15;306 ( Pt 1):247-51.
• [2] Safety, tolerability and anti-tumour activity of the androgen biosynthesis inhibitor ASP9521 in patients with metastatic castration-resistant prostate cancer: multi-centre phase I/II study. Invest New Drugs. 2014 Oct;32(5):995-1004.
• [3] Aldo-Keto Reductase (AKR) 1C3 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Dec;27(12):1329-1340.
• [4] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
• [5] New cyclopentane derivatives as inhibitors of steroid metabolizing enzymes AKR1C1 and AKR1C3. Eur J Med Chem. 2009 Jun;44(6):2563-71.
• [6] Nonsteroidal anti-inflammatory drugs and their analogues as inhibitors of aldo-keto reductase AKR1C3: new lead compounds for the development of ant... Bioorg Med Chem Lett. 2005 Dec 1;15(23):5170-5.
• [7] Structure-guided design, synthesis, and evaluation of salicylic acid-based inhibitors targeting a selectivity pocket in the active site of human 20... J Med Chem. 2009 May 28;52(10):3259-64.
• [8] Structure-based inhibitor design for an enzyme that binds different steroids: a potent inhibitor for human type 5 17beta-hydroxysteroid dehydrogenase. J Biol Chem. 2007 Mar 16;282(11):8368-79.