Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TT6804T)

• DTT Name: MIF messenger RNA (MIF mRNA) DTT Info
• Gene Name: MIF

Molecule-Related Drug & Molecule List

28 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
1-(2-chlorophenyl)-3-(pyridin-2-yl)thiourea	DMGSKAO	Discovery agent	N.A.	Investigative	[1]
1-phenyl-3-(1,3,4-thiadiazol-2-yl)thiourea	DM6QU5B	Discovery agent	N.A.	Investigative	[1]
2-(4-hydroxystyryl)quinolin-8-ol	DM8GBH4	Discovery agent	N.A.	Investigative	[2]
3,3,3-tris(4-chlorophenyl)propanoic acid	DMBFY4H	Discovery agent	N.A.	Investigative	[3]
3-(1H-pyrazol-3-yl)benzoic acid	DMKFGDI	Discovery agent	N.A.	Investigative	[2]
3-acetyl-7-hydroxy-2H-chromen-2-one	DM01WBD	Discovery agent	N.A.	Investigative	[2]
3-benzyl-5-fluorobenzo[d]oxazol-2(3H)-one	DMZ85NC	Discovery agent	N.A.	Investigative	[4]
3-benzyl-5-methylbenzo[d]oxazol-2(3H)-one	DMHYQ3Z	Discovery agent	N.A.	Investigative	[4]
3-benzyl-6-methylbenzo[d]oxazol-2(3H)-one	DMGPKIY	Discovery agent	N.A.	Investigative	[4]
4-((pyridin-4-ylthio)methyl)benzene-1,2-diol	DM7X2AY	Discovery agent	N.A.	Investigative	[3]
4-(4-benzyl-1H-1,2,3-triazol-1-yl)phenol	DMT2S9U	Discovery agent	N.A.	Investigative	[5]
4-iodo-6-phenylpyrimidine	DMYNVLZ	Solid tumour/cancer	2A00-2F9Z	Investigative	[4]
6-phenylpyridazin-3-yl thiophene-2-carboxylate	DMXTV1B	Discovery agent	N.A.	Investigative	[1]
7-hydroxy-3-phenyl-2H-chromen-2-one	DM2ZE8U	Discovery agent	N.A.	Investigative	[2]
Benzofuran-2-yl(indolin-1-yl)methanone	DMF1ZE6	Discovery agent	N.A.	Investigative	[2]
Ethyl 7-hydroxy-2-oxo-2H-chromene-3-carboxylate	DM7FPX8	Discovery agent	N.A.	Investigative	[2]
ISIS 112580	DMXHQSG	Discovery agent	N.A.	Investigative	[6]
ISIS 112590	DMU5QRX	Discovery agent	N.A.	Investigative	[6]
ISIS 112592	DM9OPJW	Discovery agent	N.A.	Investigative	[6]
ISIS 112599	DMIYCMF	Discovery agent	N.A.	Investigative	[6]
ISIS 112690	DM6PO0N	Discovery agent	N.A.	Investigative	[6]
ISIS 112694	DMA4635	Discovery agent	N.A.	Investigative	[6]
ISIS 112696	DMXZS4Y	Discovery agent	N.A.	Investigative	[6]
ISIS 112699	DMIE0GJ	Discovery agent	N.A.	Investigative	[6]
ISIS 112711	DM52UGS	Discovery agent	N.A.	Investigative	[6]
ISIS 112724	DMB2O1Y	Discovery agent	N.A.	Investigative	[6]
N-(2-bromobenzoyloxy)-4-chlorobenzamide	DMFC564	Discovery agent	N.A.	Investigative	[1]
S-benzo[d]oxazol-2-yl O-butyl carbonothioate	DMCRQ29	Discovery agent	N.A.	Investigative	[1]

References

• [1] An integrative in silico methodology for the identification of modulators of macrophage migration inhibitory factor (MIF) tautomerase activity. Bioorg Med Chem. 2010 Jul 15;18(14):5425-40.
• [2] Discovery of human macrophage migration inhibitory factor (MIF)-CD74 antagonists via virtual screening. J Med Chem. 2009 Jan 22;52(2):416-24.
• [3] Classification of chemical compounds by protein-compound docking for use in designing a focused library. J Med Chem. 2006 Jan 26;49(2):523-33.
• [4] Optimization of N-benzyl-benzoxazol-2-ones as receptor antagonists of macrophage migration inhibitory factor (MIF). Bioorg Med Chem Lett. 2010 Oct 1;20(19):5811-4.
• [5] Receptor agonists of macrophage migration inhibitory factor. Bioorg Med Chem Lett. 2010 Dec 1;20(23):7033-6.
• [6] US patent application no. 6,268,151, Antisense modulation of macrophage migration inhibitory factor expression.