Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TT69J2Z)

• DTT Name: Serine/threonine-protein kinase pim-2 (PIM2) DTT Info
• Gene Name: PIM2

Molecule-Related Drug & Molecule List

2 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
LGH-447	DMQN9ME	Multiple myeloma	2A83	Phase 1/2	[1]
AZD1208	DMBEA6V	Solid tumour/cancer	2A00-2F9Z	Phase 1	[2]

2 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
IDDBCP226234	DMBFX5H	Inflammation	1A00-CA43.1	Investigative	[3]
PMID21982499C14k	DM0VOXN	Discovery agent	N.A.	Investigative	[4]

References

• [1] Pan-PIM kinase inhibition provides a novel therapy for treating hematologic cancers. Clin Cancer Res. 2014 Apr 1;20(7):1834-45.
• [2] AZD1208, a potent and selective pan-Pim kinase inhibitor, demonstrates efficacy in preclinical models of acute myeloid leukemia. Blood. 2014 Feb 6;123(6):905-13.
• [3] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2159).
• [4] 7-(4H-1,2,4-Triazol-3-yl)benzo[c][2,6]naphthyridines: a novel class of Pim kinase inhibitors with potent cell antiproliferative activity. Bioorg Med Chem Lett. 2011 Nov 15;21(22):6687-92.