Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TT6NI13)

• DTT Name: MEK kinase kinase 4 (MAP4K4) DTT Info
• Gene Name: MAP4K4

Molecule-Related Drug & Molecule List

3 Patented Agent(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
6-Phenylquinazolin-4-amine	DMV5XR7	N. A.	N. A.	Patented	[1]
BDBM50011552	DMW5SD6	N. A.	N. A.	Patented	[1]
BDBM50011553	DMHNYQU	N. A.	N. A.	Patented	[1]

2 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PMID23312943C21	DMOJ8QR	Discovery agent	N.A.	Investigative	[2]
PMID24673130C26	DM2HVU8	Discovery agent	N.A.	Investigative	[3]

References

• [1] Aminoquinazoline and pyridopyrimidine derivatives. US9592235.
• [2] Optimization of highly selective 2,4-diaminopyrimidine-5-carboxamide inhibitors of Sky kinase. Bioorg Med Chem Lett. 2013 Feb 15;23(4):1051-5.
• [3] Discovery of selective 4-Amino-pyridopyrimidine inhibitors of MAP4K4 using fragment-based lead identification and optimization. J Med Chem. 2014 Apr 24;57(8):3484-93.