Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TT7AKW1)

• DTT Name: T-cell receptor (TCR) DTT Info
• Gene Name: TCR

Molecule-Related Drug & Molecule List

1 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tebentafusp	DMUJ1WV	Gastric cancer	2B72	Approved	[1]

8 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
IR502	DMW2IF9	Plaque psoriasis	EA90.0	Phase 2	[2]
RGI-2001	DM4AC2F	Graft-versus-host disease	4B24	Phase 2	[3]
SAR444200	DM7J5H0	Aggressive cancer	2A00-2F9Z	Phase 2	[4]
MAGE-A10 TCR	DM6H3YS	Bladder cancer	2C94	Phase 1/2	[1]
NY-ESO-TCR	DMS0L6J	Melanoma	2C30	Phase 1/2	[1]
TOL-101	DM6AXV9	Multiple sclerosis	8A40	Phase 1/2	[5]
AFP TCR	DMHBUMZ	Hepatocellular carcinoma	2C12.02	Phase 1	[1]
BPX-701	DMYERSD	Acute myeloid leukaemia	2A60	Phase 1	[1]

References

• [1] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [2] WO patent application no. 2004,0677,06, Production of multimeric proteins.
• [3] Pharmacologic expansion of donor-derived, naturally occurring CD4(+)Foxp3(+) regulatory T cells reduces acute graft-versus-host disease lethality without abrogating the graft-versus-leukemia effect in murine models. Biol Blood Marrow Transplant. 2011 Aug;17(8):1154-68.
• [4] Clinical pipeline report, company report or official report of Sanofi
• [5] First-in-Human Study of the Safety and Efficacy of TOL101 Induction to Prevent Kidney Transplant Rejection. Am J Transplant. 2014 June; 14(6): 1346-1355.