Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TT84DRB)

• DTT Name: Voltage-gated sodium channel alpha Nav1.4 (SCN4A) DTT Info
• UniProt ID: SCN4A_HUMAN
• Gene Name: SCN4A

Molecule-Related Drug & Molecule List

1 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lanperisone	DM4EGPN	Musculoskeletal disorder	FA00-FC0Z	Phase 3	[1]

2 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sipatrigine	DMMQ4GC	Neurological disorder	6B60	Discontinued in Phase 2	[2]
V-102862	DMR2EUV	N. A.	N. A.	Discontinued in Phase 1	[3]

15 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
3-(4-Phenoxy-phenyl)-1H-pyrazole	DMO6LID	Discovery agent	N.A.	Investigative	[3]
3-[4-(4-Fluoro-phenoxy)-phenyl]-1H-pyrazole	DME86OK	Discovery agent	N.A.	Investigative	[3]
Batrachotoxin	DMYH9SU	Discovery agent	N.A.	Investigative	[4]
BW-202W92	DMFKXMT	Discovery agent	N.A.	Investigative	[2]
CCACSSKWCRDHSRCC	DMSE20Y	Discovery agent	N.A.	Investigative	[5]
CCNCASKWCRDHSRCC	DMRFA5O	Discovery agent	N.A.	Investigative	[5]
CCNCSAKWCRDHSRCC	DMZKJ37	Discovery agent	N.A.	Investigative	[5]
CCNCSSKWCRAHSRCC	DM96YR2	Discovery agent	N.A.	Investigative	[5]
CCNCSSKWCRDHARCC	DMP0C7B	Discovery agent	N.A.	Investigative	[5]
CCNCSSKWCRDHSRCC	DMBGHTW	Discovery agent	N.A.	Investigative	[5]
grayanotoxin III	DMXSWF6	Discovery agent	N.A.	Investigative	[6]
Veratridine	DMUF8JZ	Discovery agent	N.A.	Investigative	[4]
XEP-018	DMVTCZ1	Pain	MG30-MG3Z	Investigative	[7]
ZNCCNCSSKWCRDHSRCC	DMY2V37	Discovery agent	N.A.	Investigative	[5]
ZRCCNCSSKWCRDHSRCC	DM1YZJ3	Discovery agent	N.A.	Investigative	[5]

References

• [1] Tolperisone-type drugs inhibit spinal reflexes via blockade of voltage-gated sodium and calcium channels. J Pharmacol Exp Ther. 2005 Dec;315(3):1237-46.
• [2] Oxadiazolylindazole sodium channel modulators are neuroprotective toward hippocampal neurones. J Med Chem. 2009 May 14;52(9):2694-707.
• [3] 3-(4-phenoxyphenyl)pyrazoles: a novel class of sodium channel blockers. J Med Chem. 2004 Mar 11;47(6):1547-52.
• [4] Point mutations in segment I-S6 render voltage-gated Na+ channels resistant to batrachotoxin. Proc Natl Acad Sci U S A. 1998 Mar 3;95(5):2653-8.
• [5] Structure/function characterization of micro-conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels. J Biol Chem. 2007 Oct 19;282(42):30699-706.
• [6] Novel site on sodium channel alpha-subunit responsible for the differential sensitivity of grayanotoxin in skeletal and cardiac muscle. Mol Pharmacol. 2001 Oct;60(4):865-72.
• [7] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 581).