Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TT8CWFK)

• DTT Name: Toll-like receptor 8 (TLR8) DTT Info
• Gene Name: TLR8

Molecule-Related Drug & Molecule List

11 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Afimetoran	DM3HN3U	Systemic lupus erythematosus	4A40.0	Phase 2	[1]
Resiquimod	DML6XSP	Actinic keratosis	EK90.0	Phase 2	[2]
Selgantolimod	DMST4OR	Hepatitis B	1E51	Phase 2	[3]
NKTR-262	DMYR8LF	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[4]
CPG 52364	DMVDYTG	Systemic lupus erythematosus	4A40.0	Phase 1	[5]
CV8102	DMYD37G	Melanoma	2C30	Phase 1	[6]
DN1508052	DM0JT9C	Solid tumour/cancer	2A00-2F9Z	Phase 1	[7]
GSK5251738	DM8Y6DR	Hepatitis B	1E51	Phase 1	[8]
MEDI9197	DM0J7UR	Solid tumour/cancer	2A00-2F9Z	Phase 1	[9]
SBT6050	DMHBD3T	Solid tumour/cancer	2A00-2F9Z	Phase 1	[10]
VTX-1463	DM4ZIRK	Allergic rhinitis	CA08.0	Phase 1	[11]

2 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
VTX-2337	DMLCTBP	Allergy	4A80-4A85	Discontinued in Phase 2	[12]
IM0-8400	DMEF9JW	Diffuse large B-cell lymphoma	2A81	Discontinued in Phase 1/2	[13]

3 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ODN-1411	DM0GVZO	Rheumatoid arthritis	FA20	Investigative	[14]
VTX-744	DMEVAIF	Discovery agent	N.A.	Investigative	[15]
VTX-763	DMGTB95	Autoimmune diabetes	5A10	Investigative	[15]

References

• [1] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2023. Adis Insight
• [2] TLR agonists as vaccine adjuvants: comparison of CpG ODN and Resiquimod (R-848).Vaccine.2005 Nov 1;23(45):5263-70.
• [3] Discovery of GS-9688 (Selgantolimod) as a Potent and Selective Oral Toll-Like Receptor 8 Agonist for the Treatment of Chronic Hepatitis B. J Med Chem. 2020 Sep 24;63(18):10188-10203.
• [4] Clinical pipeline report, company report or official report of Nektar Therapeutics.
• [5] Coley Pharmaceutical Group Diversifies Pipeline with First-in-Class TLR Antagonist for the Treatment of Systemic Lupus Erythematosus. Lupus Foundation of America, Inc. 2007.
• [6] Clinical pipeline report, company report or official report of CureVac.
• [7] Clinical pipeline report, company report or official report of Shanghai De Novo Pharmatech.
• [8] Clinical pipeline report, company report or official report of GlaxoSmithKline
• [9] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [10] Clinical pipeline report, company report or official report of Silverback Therapeutics.
• [11] VTX-1463, a novel TLR8 agonist for the treatment of allergic rhinitis. Expert Opin Investig Drugs. 2011 Jul;20(7):981-6.
• [12] Clinical pipeline report, company report or official report of Array BioPharma (Drug: Motolimod / VTX2337).
• [13] Clinical pipeline report, company report or official report of Idera Pharmaceuticals.
• [14] Oligodeoxynucleotide inhibition of Toll-like receptors 3, 7, 8, and 9 suppresses cytokine production in a human rheumatoid arthritis model. Eur J Immunol. 2016 Mar;46(3):772-81.
• [15] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1758).