Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TT8J1S3)

DTT Name	Smoothened homolog (SMO) DTT Info
Gene Name	SMO

Molecule-Related Drug & Molecule List

Molecule-Related Drug List

Molecule Type:

DTT

DTP

DME

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Patented Agent(s)

Investigative Drug(s)

Download the Complete Related Drug List

2 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PF-04449913	DMSB068	Chronic myelomonocytic leukaemia	2A40	Approved	[1]
Vismodegib	DM5IXKQ	Basal cell carcinoma	2C32	Approved	[2]
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5 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
LDE225	DMM9F25	Basal cell carcinoma	2C32	Phase 2	[3]
LY2940680	DMTJWIQ	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[1]
BMS-833923	DM459Q7	Solid tumour/cancer	2A00-2F9Z	Phase 1b	[4]
LEQ-506	DM5INZP	Solid tumour/cancer	2A00-2F9Z	Phase 1	[5]
TAK-441	DM7DFBL	Solid tumour/cancer	2A00-2F9Z	Phase 1	[6]
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75 Patented Agent(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bicyclic hexapeptide derivative 1	DMWTCM8	N. A.	N. A.	Patented	[7]
Bicyclic hexapeptide derivative 2	DMJP1IK	N. A.	N. A.	Patented	[7]
Cyclic sulfonamide derivative 1	DMJMWDV	N. A.	N. A.	Patented	[7]
Cyclic sulfonamide derivative 2	DMXSZ5B	N. A.	N. A.	Patented	[7]
Cyclic sulfonamide derivative 3	DMBANT7	N. A.	N. A.	Patented	[7]
Cyclic sulfonamide derivative 4	DMWAU49	N. A.	N. A.	Patented	[7]
Imidazo bicyclic iminium derivative 3	DMENYZ0	N. A.	N. A.	Patented	[7]
Imidazo bicyclic iminium derivative 4	DMHRV8J	N. A.	N. A.	Patented	[7]
Imidazo bicyclic iminium derivative 5	DMS8GIU	N. A.	N. A.	Patented	[7]
Imidazo bicyclic iminium derivative 6	DMEP5MJ	N. A.	N. A.	Patented	[7]
Imidazo bicyclic iminium derivative 7	DM0Y4X8	N. A.	N. A.	Patented	[7]
Imidazo bicyclic iminium derivative 8	DMBMFPC	N. A.	N. A.	Patented	[7]
Imidazo bicyclic iminium derivative 9	DMQXCT1	N. A.	N. A.	Patented	[7]
Isoflavone derivative 1	DMMCWH9	N. A.	N. A.	Patented	[8]
Isoflavone derivative 2	DMTWAH3	N. A.	N. A.	Patented	[8]
Isoflavone derivative 3	DMYFKR2	N. A.	N. A.	Patented	[8]
Isoflavone derivative 4	DMYRU7I	N. A.	N. A.	Patented	[8]
Isoflavone derivative 5	DM2GL47	N. A.	N. A.	Patented	[8]
Isoflavone derivative 6	DM2ZYVL	N. A.	N. A.	Patented	[8]
Isoflavone derivative 7	DMNCHBL	N. A.	N. A.	Patented	[8]
Isoflavone derivative 8	DMN0XJQ	N. A.	N. A.	Patented	[8]
Isoflavone derivative 9	DMA78MD	N. A.	N. A.	Patented	[8]
PMID25726713-Compound-10	DMZ73D9	N. A.	N. A.	Patented	[7]
PMID25726713-Compound-11	DMN42OT	N. A.	N. A.	Patented	[7]
PMID25726713-Compound-12	DMD3AHN	N. A.	N. A.	Patented	[7]
PMID25726713-Compound-13	DM8LZ60	N. A.	N. A.	Patented	[7]
PMID25726713-Compound-14	DM6ORB9	N. A.	N. A.	Patented	[7]
PMID25726713-Compound-15	DM67WM4	N. A.	N. A.	Patented	[7]
PMID25726713-Compound-16	DM3BOZP	N. A.	N. A.	Patented	[7]
PMID25726713-Compound-17	DM9MFUN	N. A.	N. A.	Patented	[7]
PMID25726713-Compound-18	DMP7C5L	N. A.	N. A.	Patented	[7]
PMID25726713-Compound-19	DMQJZLI	N. A.	N. A.	Patented	[7]
PMID25726713-Compound-20	DMZOG9S	N. A.	N. A.	Patented	[7]
PMID25726713-Compound-21	DMB0DS5	N. A.	N. A.	Patented	[7]
PMID25726713-Compound-22	DMJUHXB	N. A.	N. A.	Patented	[7]
PMID25726713-Compound-23	DMEXNOP	N. A.	N. A.	Patented	[7]
PMID25726713-Compound-24	DMMFK2Q	N. A.	N. A.	Patented	[7]
PMID25726713-Compound-25	DMLCPWT	N. A.	N. A.	Patented	[7]
PMID25726713-Compound-26	DMJ8MXZ	N. A.	N. A.	Patented	[7]
PMID25726713-Compound-27	DMTL73W	N. A.	N. A.	Patented	[7]
PMID25726713-Compound-28	DMYM60P	N. A.	N. A.	Patented	[7]
PMID25726713-Compound-29	DM3QU80	N. A.	N. A.	Patented	[7]
PMID25726713-Compound-30	DMFBHAC	N. A.	N. A.	Patented	[7]
PMID25726713-Compound-31	DMN13BI	N. A.	N. A.	Patented	[7]
PMID25726713-Compound-32	DMIFH8T	N. A.	N. A.	Patented	[7]
PMID25726713-Compound-33	DMEQ9BN	N. A.	N. A.	Patented	[7]
PMID25726713-Compound-34	DMCXDKS	N. A.	N. A.	Patented	[7]
PMID25726713-Compound-35	DMYCABN	N. A.	N. A.	Patented	[7]
PMID25726713-Compound-36	DMYPT63	N. A.	N. A.	Patented	[7]
PMID25726713-Compound-37	DMGXOJK	N. A.	N. A.	Patented	[7]
PMID25726713-Compound-38	DM4XJST	N. A.	N. A.	Patented	[7]
PMID25726713-Compound-39	DMVL25C	N. A.	N. A.	Patented	[7]
PMID25726713-Compound-42	DM5E2B3	N. A.	N. A.	Patented	[7]
PMID25726713-Compound-43	DME9QCM	N. A.	N. A.	Patented	[7]
PMID25726713-Compound-44	DMEFA20	N. A.	N. A.	Patented	[7]
PMID25726713-Compound-45	DMR8OVI	N. A.	N. A.	Patented	[7]
PMID25726713-Compound-46	DM27DQP	N. A.	N. A.	Patented	[7]
PMID25726713-Compound-47	DMXE5KM	N. A.	N. A.	Patented	[7]
PMID25726713-Compound-48	DMSIOUA	N. A.	N. A.	Patented	[7]
PMID25726713-Compound-49	DM2CT4G	N. A.	N. A.	Patented	[7]
PMID25726713-Compound-50	DM3BDFV	N. A.	N. A.	Patented	[7]
PMID25726713-Compound-51	DMF0OW4	N. A.	N. A.	Patented	[7]
PMID25726713-Compound-56	DMUHEP8	N. A.	N. A.	Patented	[7]
PMID25726713-Compound-57	DMMZHB1	N. A.	N. A.	Patented	[7]
PMID25726713-Compound-58	DMPDX3L	N. A.	N. A.	Patented	[7]
PMID25726713-Compound-59	DMBF1OG	N. A.	N. A.	Patented	[7]
PMID25726713-Compound-60	DMR8HSU	N. A.	N. A.	Patented	[7]
PMID25726713-Compound-61	DMYXK7I	N. A.	N. A.	Patented	[7]
PMID25726713-Compound-62	DMXNLTR	N. A.	N. A.	Patented	[7]
PMID25726713-Compound-63	DMT0QLO	N. A.	N. A.	Patented	[7]
PMID25726713-Compound-64	DM6A8TS	N. A.	N. A.	Patented	[7]
Pyrimidine derivative 19	DMLPO0K	N. A.	N. A.	Patented	[7]
Pyrimidine derivative 20	DMQUEDK	N. A.	N. A.	Patented	[7]
Pyrimidine derivative 21	DMELA2F	N. A.	N. A.	Patented	[7]
Pyrimidine derivative 22	DMN64AK	N. A.	N. A.	Patented	[7]
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⏷ Show the Full List of 75 Patented Agent(s)

4 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
1-Benzyl-4-(4-phenylpiperazin-1-yl)phthalazine	DM4NGUL	Discovery agent	N.A.	Investigative	[9]
AZD8542	DM0HTXO	Discovery agent	N.A.	Investigative	[10]
CYCLOPAMINE	DMEM2SW	Discovery agent	N.A.	Investigative	[11]
SMOi2-17	DMABIX1	Solid tumour/cancer	2A00-2F9Z	Investigative	[10]
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Molecule Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

References

1	Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
2	Nat Rev Drug Discov. 2013 Feb;12(2):87-90.
3	Inhibition of Hedgehog signalling by NVP-LDE225 (Erismodegib) interferes with growth and invasion of human renal cell carcinoma cells. Br J Cancer. 2014 Sep 9;111(6):1168-79.
4	Clinical pipeline report, company report or official report of Exelixis (2011).
5	Discovery of NVP-LEQ506, a second-generation inhibitor of smoothened. ChemMedChem. 2013 Aug;8(8):1261-5.
6	TAK-441, a novel investigational smoothened antagonist, delays castration-resistant progression in prostate cancer by disrupting paracrine hedgehog signaling. Int J Cancer. 2013 Oct 15;133(8):1955-66.
7	Hedgehog inhibitors: a patent review (2013 - present).Expert Opin Ther Pat. 2015 May;25(5):549-65.
8	Evaluation of WO2014207069 A1: Multitarget Hedgehog pathway inhibitors and uses thereof.Expert Opin Ther Pat. 2016;26(4):529-35.
9	1-amino-4-benzylphthalazines as orally bioavailable smoothened antagonists with antitumor activity. J Med Chem. 2009 Jul 9;52(13):3954-68.
10	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 239).
11	Identification and structure-activity relationships of ortho-biphenyl carboxamides as potent Smoothened antagonists inhibiting the Hedgehog signali... Bioorg Med Chem Lett. 2009 Jan 15;19(2):328-31.