General Information of DTT (ID: TTC70AJ)

DTT Name Granulocyte colony-stimulating factor receptor (G-CSF-R) DTT Info
Gene Name CSF3R

Molecule-Related Drug & Molecule List

Molecule-Related Drug List
Molecule Type:
DTT
DTP
DME
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
2 Approved Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
Pegfilgrastim DM7UP8X Central nervous system neoplasm Approved [1]
Tbo-Filgrastim DML6OE7 Neutropenia 4B00.0 Approved [2]
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9 Clinical Trial Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
Peg-G-CSF DMBKWAF Solid tumour/cancer 2A00-2F9Z Phase 3 [3]
AX-200 DMTAEMB Cardiovascular disease BA00-BE2Z Phase 2 [4]
BLZ-945 DMG1LVA Amyotrophic lateral sclerosis 8B60.0 Phase 2 [3]
MAXY-G34 DMWLIPJ Neutropenia 4B00.0 Phase 2 [5]
SBC-014 DMG1VXR Neutropenia 4B00.0 Phase 2 [6]
AMG 820 DMB6Q19 Solid tumour/cancer 2A00-2F9Z Phase 1 [7]
MK-6302 DMZUA5C Neutropenia 4B00.0 Phase 1 [8]
PLX-5622 DMK4PWM Autoimmune diabetes 5A10 Phase 1 [9]
PLX7486 DM0IVGU Pancreatic cancer 2C10 Phase 1 [10]
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⏷ Show the Full List of 9 Clinical Trial Drug(s)
1 Discontinued Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
ZD-6003 DMU2F6Q Solid tumour/cancer 2A00-2F9Z Terminated [3]
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7 Investigative Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
AC-710 DMXS72J Autoimmune diabetes 5A10 Investigative [3]
AZD-7507 DMLJPDW Solid tumour/cancer 2A00-2F9Z Investigative [3]
CSL-324 DMTN1P2 Inflammation 1A00-CA43.1 Investigative [3]
G-CSF DMVFDYU leukaemia 2A60-2B33 Investigative [3]
N-(2-morpholinophenyl)-5-nitrofuran-2-carboxamide DMI4KNB Discovery agent N.A. Investigative [11]
TG-3003 DMHTEMP Solid tumour/cancer 2A00-2F9Z Investigative [3]
ZP-G-CSF DM9XFYZ Neutropenia 4B00.0 Investigative [3]
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⏷ Show the Full List of 7 Investigative Drug(s)
Molecule Interaction Atlas

References

1 Evidence that the granulocyte colony-stimulating factor (G-CSF) receptor plays a role in the pharmacokinetics of G-CSF and PegG-CSF using a G-CSF-R KO model. Pharmacol Res. 2004 Jul;50(1):55-8.
2 Nat Rev Drug Discov. 2013 Feb;12(2):87-90.
3 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1719).
4 Granulocyte colony-stimulating factor in patients with acute ischemic stroke: results of the AX200 for Ischemic Stroke trial. Stroke. 2013 Oct;44(10):2681-7.
5 Survival efficacy of the PEGylated G-CSFs Maxy-G34 and neulasta in a mouse model of lethal H-ARS, and residual bone marrow damage in treated survivors. Health Phys. 2014 Jan;106(1):21-38.
6 A glycosylated recombinant human granulocyte colony stimulating factor produced in a novel protein production system (AVI-014) in healthy subjects: a first-in human, single dose, controlled study. BMC Clin Pharmacol. 2009; 9: 2.
7 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
8 Merck ditches biogeneric. Nat Biotechnol. 2010 Jul;28(7):636.
9 Microglial Stimulation of Glioblastoma Invasion Involves Epidermal Growth Factor Receptor (EGFR) and Colony Stimulating Factor 1 Receptor (CSF-1R) Signaling. Mol Med. 2012; 18(1): 519-527.
10 National Cancer Institute Drug Dictionary (drug id 747694).
11 Potent 2'-aminoanilide inhibitors of cFMS as potential anti-inflammatory agents. Bioorg Med Chem Lett. 2007 Nov 15;17(22):6070-4.