Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTCJUR4)

• DTT Name: Exportin-1 (XPO1) DTT Info
• Gene Name: XPO1

Molecule-Related Drug & Molecule List

4 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selinexor	DMBD4K3	Multiple myeloma	2A83	Phase 3	[1]
Selinexor oral	DMDLOBZ	Recurrent glioblastoma	2A00.00	Phase 2	[2]
Eltanexor oral	DM7CLEZ	Colorectal cancer	2B91.Z	Phase 1/2	[3]
SL-801	DMIVGYK	Solid tumour/cancer	2A00-2F9Z	Phase 1	[3]

1 Preclinical Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
KOS-1815	DMCGFY6	Solid tumour/cancer	2A00-2F9Z	Preclinical	[1]

2 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Octahydrocurcumin	DMUFDR6	Solid tumour/cancer	2A00-2F9Z	Investigative	[4]
S109	DM2JYQA	Solid tumour/cancer	2A00-2F9Z	Investigative	[5]

References

• [1] Inhibition of CRM1-dependent nuclear export sensitizes malignant cells to cytotoxic and targeted agents. Semin Cancer Biol. 2014 August; 0: 62-73.
• [2] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [3] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [4] Therapeutic strategies targeting FOXO transcription factors. Nat Rev Drug Discov. 2021 Jan;20(1):21-38.
• [5] Reversible inhibitor of CRM1 sensitizes glioblastoma cells to radiation by blocking the NF-B signaling pathway. Cancer Cell Int. 2020 Mar 30;20:97.