Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTCYE56)

• DTT Name: Glutathione-dependent PGD synthase (HPGDS) DTT Info
• Gene Name: HPGDS

Molecule-Related Drug & Molecule List

1 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Praziquantel	DMOU1PK	Flatworm infection	1F70-1F86	Approved	[1]

1 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
HF-0220	DMI4C90	Alzheimer disease	8A20	Phase 2	[2]

5 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cibacron blue	DMWE1N8	Discovery agent	N.A.	Investigative	[3]
Formic Acid	DMNFZC6	Discovery agent	N.A.	Investigative	[4]
HQL-79	DMSHYQ3	Discovery agent	N.A.	Investigative	[5]
Protoporphyrin IX	DMWYE7A	Discovery agent	N.A.	Investigative	[6]
S-hexylglutathione	DMNWP02	Discovery agent	N.A.	Investigative	[7]

References

• [1] X-ray structure of glutathione S-transferase from Schistosoma japonicum in a new crystal form reveals flexibility of the substrate-binding site. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Mar 1;61(Pt 3):263-5.
• [2] US patent application no. 2009,0062,529, Multi-cyclic compounds.
• [3] A novel method for screening the glutathione transferase inhibitors. BMC Biochem. 2009 Mar 16;10:6.
• [4] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
• [5] Structural and functional characterization of HQL-79, an orally selective inhibitor of human hematopoietic prostaglandin D synthase. J Biol Chem. 2006 Jun 2;281(22):15277-86.
• [6] Inhibition of glutathione-S-transferase from Plasmodium yoelii by protoporphyrin IX, cibacron blue and menadione: implications and therapeutic bene... Parasitol Res. 2008 Mar;102(4):805-7.
• [7] Purification and catalytic properties of glutathione transferase from the hepatopancreas of crayfish macrobrachium vollenhovenii (herklots). J Biochem Mol Toxicol. 2004;18(6):332-44.