Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTD3XFU)

• DTT Name: C-C chemokine receptor type 3 (CCR3) DTT Info
• Gene Name: CCR3

Molecule-Related Drug & Molecule List

1 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AKST4290	DM27ZJG	Parkinson disease	8A00.0	Phase 2	[1]

3 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AZD-1744	DMCOMG5	Asthma	CA23	Discontinued in Phase 1	[2]
DPC-168	DMA7DH0	Allergic rhinitis	CA08.0	Discontinued in Phase 1	[3]
QAP-642	DM8RHST	Allergic rhinitis	CA08.0	Terminated	[5]

2 Preclinical Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
YM-344031	DMMUYC2	Asthma	CA23	Preclinical	[4]
YM-355179	DMTM1LK	Asthma	CA23	Preclinical	[4]

References

• [1] SAFETY AND THERAPEUTIC EFFECTS OF ORALLY ADMINISTERED AKST4290 IN NEWLY DIAGNOSED NEOVASCULAR AGE-RELATED MACULAR DEGENERATION. Retina. 2022 Jun 1;42(6):1038-1046.
• [2] Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
• [3] CC chemokine receptor-3 (CCR3) antagonists: improving the selectivity of DPC168 by reducing central ring lipophilicity. Bioorg Med Chem Lett. 2007 Jun 1;17(11):2992-7.
• [4] Emerging drugs for asthma. Expert Opin Emerg Drugs. 2008 Dec;13(4):643-53.
• [5] New Drugs and Targets for Asthma and COPD. T.T. Hansel, P.J. Barnes. 2010. Page 158.