Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTE836A)

• DTT Name: C-C chemokine receptor type 8 (CCR8) DTT Info
• Gene Name: CCR8

Molecule-Related Drug & Molecule List

1 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
GS-1811	DMCEMC6	Solid tumour/cancer	2A00-2F9Z	Phase 1	[1]

1 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
CCX-832	DMD8QHV	Psoriasis vulgaris	EA90	Discontinued in Phase 1	[2]

5 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
I-309	DM7QE51	Discovery agent	N.A.	Investigative	[3]
N-(4-phenylsulfamoyl-naphthalen-1-yl)-benzamide	DMQS9OH	Discovery agent	N.A.	Investigative	[4]
N-{4-[(benzylamino)sulfonyl]-1-naphthyl}benzamide	DM74KHG	Discovery agent	N.A.	Investigative	[4]
viral macrophage inflammatory protein-II	DMAXOPS	Discovery agent	N.A.	Investigative	[5]
ZK 756326	DMP089G	Discovery agent	N.A.	Investigative	[6]

References

• [1] Differential expression of CCR8 in tumors versus normal tissue allows specific depletion of tumor-infiltrating T regulatory cells by GS-1811, a novel Fc-optimized anti-CCR8 antibody. Oncoimmunology. 2022 Nov 4;11(1):2141007.
• [2] Increased Expression of Chemerin in Squamous Esophageal Cancer Myofibroblasts and Role in Recruitment of Mesenchymal Stromal Cells. PLoS One. 2014; 9(8): e104877.
• [3] The chemokine receptor CCR8 is preferentially expressed in Th2 but not Th1 cells. J Immunol. 1998 Jul 15;161(2):547-51.
• [4] Design, synthesis, and evaluation of naphthalene-sulfonamide antagonists of human CCR8. J Med Chem. 2007 Feb 8;50(3):566-84.
• [5] HHV8-encoded vMIP-I selectively engages chemokine receptor CCR8. Agonist and antagonist profiles of viral chemokines. J Biol Chem. 1999 Jul 30;274(31):21569-74.
• [6] Identification and characterization of a potent, selective nonpeptide agonist of the CC chemokine receptor CCR8. Mol Pharmacol. 2006 Jan;69(1):309-16.