Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTEMV5X)

• DTT Name: Serine protease unspecific (SP) DTT Info
• Gene Name: SP

Molecule-Related Drug & Molecule List

4 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aprotinin	DM0QD4W	Bleeding disorder	GA20-GA21	Approved	[1]
Gabexate	DMU9D2F	Pancreatitis	DC31-DC34	Approved	[2]
Nafamostat	DMU1XOD	Pancreatitis	DC31-DC34	Approved	[2]
Sivelestat sodium hydrate	DMOSJD0	Acute lung injury	NB32.3	Phase 4	[3]

2 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Camostat	DMQ7UL8	Cystic fibrosis	CA25	Phase 2	[4]
VT-111a	DMY9ZGN	Acute coronary syndrome	BA41	Phase 2	[5]

3 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sepimostat mesylate	DMRBYH8	Solid tumour/cancer	2A00-2F9Z	Discontinued in Phase 3	[6]
NPI-1999	DMH1YL8	Thrombosis	DB61-GB90	Terminated	[8]
SDZ-MTH-958	DMKCXBJ	Artery stenosis	BD52	Terminated	[9]

1 Preclinical Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
VT-111	DMOY15R	Graft rejection in heart transplantation	NE84	Preclinical	[7]

References

• [1] Randomized controlled trials of aprotinin in cardiac surgery: could clinical equipoise have stopped the bleeding Clin Trials. 2005;2(3):218-29; discussion 229-32.
• [2] Tryptase-positive mast cells correlate with angiogenesis in early breast cancer patients. Int J Oncol. 2009 Jul;35(1):115-20.
• [3] Emerging drugs for the treatment of chronic obstructive pulmonary disease. Expert Opin Emerg Drugs. 2006 May;11(2):275-91.
• [4] Camostat mesilate inhibits prostasin activity and reduces blood pressure and renal injury in salt-sensitive hypertension. J Hypertens. 2009 Jan;27(1):181-9.
• [5] Viral Serpin Therapeutics: From Concept to Clinic. Methods Enzymol. 2011; 499: 301-329.
• [6] Effect of FUT-187, oral serine protease inhibitor, on inflammation in the gastric remnant. Gan To Kagaku Ryoho. 1996 Dec;23(14):1971-9.
• [7] New developments in immunosuppressive therapy for heart transplantation. Expert Opin Emerg Drugs. 2009 Mar;14(1):1-21.
• [8] US patent application no. 2005,0096,323, Diketopiperazine derivatives to inhibit thrombin.
• [9] Thrombin inhibition in an ex vivo model of porcine heart xenograft hyperacute rejection. Transplantation. 1996 Mar 27;61(6):862-8.