Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTEXB9Z)

• DTT Name: Glycinamide ribonucleotide formyltransferase (GART) DTT Info
• Gene Name: GART

Molecule-Related Drug & Molecule List

2 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PELITREXOL	DMR6USG	Solid tumour/cancer	2A00-2F9Z	Phase 2	[1]
LY309887	DMJPCHK	Solid tumour/cancer	2A00-2F9Z	Phase 1	[2]

7 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
(10r)-10-Formyl-5,8,10-Trideazafolic Acid	DMVTLF9	Discovery agent	N.A.	Investigative	[3]
10-CF3C(OH)2-DDACTHF	DMQOUJ7	Discovery agent	N.A.	Investigative	[3]
10-Formyl-5,8,10-Trideazafolic Acid	DMEBHML	Discovery agent	N.A.	Investigative	[3]
10-trifluoroacetyl-DDACTHF	DMEAGI6	Discovery agent	N.A.	Investigative	[4]
Dideazaacyclotetrahydrofolic acid	DM9WU3R	Discovery agent	N.A.	Investigative	[5]
Dideazafolate	DMAIOC9	Discovery agent	N.A.	Investigative	[6]
Glycinamide Ribonucleotide	DMW180Y	Discovery agent	N.A.	Investigative	[3]

References

• [1] Results of 2 phase I studies of intravenous (iv) pelitrexol (AG2037), a glycinamide ribonucleotide formyltransferase (GARFT) inhibitor, in patients (pts) with solid tumors. J Clin Oncol (Meeting Abstracts) July 2004 vol. 22 no. 14_suppl 3075.
• [2] New antimetabolites in cancer chemotherapy and their clinical impact. Br J Cancer. 1998;78 Suppl 3:1-7.
• [3] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
• [4] Discovery of a potent, nonpolyglutamatable inhibitor of glycinamide ribonucleotide transformylase. J Med Chem. 2006 May 18;49(10):2998-3002.
• [5] Asymmetric synthesis of inhibitors of glycinamide ribonucleotide transformylase. J Med Chem. 2008 Sep 11;51(17):5441-8.
• [6] N10-substituted 5,8-dideazafolate inhibitors of glycinamide ribonucleotide transformylase. J Med Chem. 1987 Jul;30(7):1254-6.