Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTF0RCZ)

• DTT Name: Apoptosis mediating surface antigen FAS (FAS) DTT Info
• Gene Name: FAS

Molecule-Related Drug & Molecule List

4 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
VB-111	DMX04CA	Malignant glioma	2A00.0	Phase 3	[1]
APG-101	DM0FXMZ	Cerebrovascular ischaemia	8B1Z	Phase 2	[2]
DE-098	DM5XT3G	Rheumatoid arthritis	FA20	Phase 2	[3]
APO-010	DMPJBCR	Multiple myeloma	2A83	Phase 1	[4]

3 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2-aminophenoxazine-3-one	DMBVGAO	T-cell leukaemia	2A90	Investigative	[5]
APG-103	DMR93WE	Inflammation	1A00-CA43.1	Investigative	[6]
F61F12	DMD7HO8	Solid tumour/cancer	2A00-2F9Z	Investigative	[6]

References

• [1] Phase I dose-escalation study of VB-111, an antiangiogenic virotherapy, in patients with advanced solid tumors.Clin Cancer Res.2013 Jul 15;19(14):3996-4007.
• [2] Pharmacokinetics, pharmacodynamics, safety and tolerability of APG101, a CD95-Fc fusion protein, in healthy volunteers and two glioma patients. Int Immunopharmacol. 2012 May;13(1):93-100.
• [3] ARG098, a novel anti-human Fas antibody, suppresses synovial hyperplasia and prevents cartilage destruction in a severe combined immunodeficient-HuRAg mouse model. BMC Musculoskeletal Disorders 2010,11:221.
• [4] APO010, a synthetic hexameric CD95 ligand, induces human glioma cell death in vitro and in vivo. Neuro Oncol. 2011 Feb;13(2):155-64.
• [5] Apoptosis as a mechanism for the treatment of adult T cell leukemia: promising drugs from benchside to bedside. Drug Discov Today. 2020 Jul;25(7):1189-1197.
• [6] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1875).