Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTF8P9I)

• DTT Name: Diacylglycerol acyltransferase 1 (DGAT1) DTT Info
• Gene Name: DGAT1

Molecule-Related Drug & Molecule List

1 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hesperetin	DMKER83	High blood cholesterol level	5C80.00	Approved	[1]

3 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
LCQ908	DMFLJHQ	Familial chylomicronemia syndrome	5C80	Phase 3	[2]
AZD7687	DMS9I6A	Diabetic complication	5A2Y	Phase 1	[3]
P-7435	DMNZQU5	Diabetic complication	5A2Y	Phase 1	[4]

21 Patented Agent(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
amidepsines	DM1FUOY	N. A.	N. A.	Patented	[5]
Azole derivative 6	DMTMJ7S	N. A.	N. A.	Patented	[5]
Azole derivative 7	DMVUJGI	N. A.	N. A.	Patented	[5]
Benzamide derivative 19	DM5YNTM	N. A.	N. A.	Patented	[5]
Carbamide derivative 3	DM4ISCQ	N. A.	N. A.	Patented	[5]
Lactam derivative 1	DMDYKPC	N. A.	N. A.	Patented	[5]
Lactam derivative 2	DMT58QE	N. A.	N. A.	Patented	[5]
Lactam derivative 3	DMD0XIL	N. A.	N. A.	Patented	[5]
Lactam derivative 4	DMJ3ZAI	N. A.	N. A.	Patented	[5]
Lactam derivative 5	DMX5FYZ	N. A.	N. A.	Patented	[5]
PMID25470667-Compound-AZD3988	DM6EN54	N. A.	N. A.	Patented	[5]
PMID25470667-Compound-BAY744113	DMY3140	N. A.	N. A.	Patented	[5]
PMID25470667-Compound-Figure4-1A	DMMVQW8	N. A.	N. A.	Patented	[5]
PMID25470667-Compound-PF-04620110	DM0OBAW	N. A.	N. A.	Patented	[5]
Pyrazine carboxamide derivative 1	DM3RAU4	N. A.	N. A.	Patented	[5]
Pyrazolo[1,5-a]pyrimidine derivative 28	DMG1RNL	N. A.	N. A.	Patented	[5]
Pyrazolo[1,5-a]pyrimidine derivative 29	DMCT6QW	N. A.	N. A.	Patented	[5]
Pyridine-amide derivative 1	DM9KOYX	N. A.	N. A.	Patented	[5]
Pyridine-carboximide derivative 1	DM25M8D	N. A.	N. A.	Patented	[5]
Pyridine-carboximide derivative 2	DMHXWZB	N. A.	N. A.	Patented	[5]
T863	DMX41ZF	Discovery agent	N.A.	Patented	[5]

3 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
DS-7250	DMQK53O	Diabetic complication	5A2Y	Discontinued in Phase 1	[6]
JTT-553	DMI7Z1Y	Obesity	5B81	Discontinued in Phase 1	[7]
PF-04620110	DMSNOH3	Type-2 diabetes	5A11	Terminated	[8]

References

• [1] In vitro inhibition of diacylglycerol acyltransferase by prenylflavonoids from Sophora flavescens. Planta Med. 2004 Mar;70(3):258-60.
• [2] DGAT1 inhibitors as anti-obesity and anti-diabetic agents. Curr Opin Drug Discov Devel. 2010 Jul;13(4):489-96.
• [3] Clinical pipeline report, company report or official report of AstraZeneca (2011).
• [4] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800033014)
• [5] Acyltransferase inhibitors: a patent review (2010-present).Expert Opin Ther Pat. 2015 Feb;25(2):145-58.
• [6] Clinical pipeline report, company report or official report of Daiichi Sankyo.
• [7] JTT-553, a novel Acyl CoA:diacylglycerol acyltransferase (DGAT) 1 inhibitor, improves glucose metabolism in diet-induced obesity and genetic T2DM mice. J Pharmacol Sci. 2015 Sep;129(1):51-8.
• [8] Clinical pipeline report, company report or official report of Pfizer (2011).