General Information of DTT (ID: TTFJ8Q1)

DTT Name Protein kinase C alpha (PRKCA) DTT Info
Gene Name PRKCA

Molecule-Related Drug & Molecule List

Molecule-Related Drug List
Molecule Type:
DTT
DTP
DME
Drug Status:
Discontinued Drug(s)
Approved Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Investigative Drug(s)
1 Approved Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sodium phenylbutyrate DMXLBCQ Spinal muscular atrophy 8B61 Approved [1]
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1 Clinical Trial Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sotrastaurin acetate DME53YS Renal transplantation NE84 Phase 2 [2]
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1 Patented Agent(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
PMID28460551-Compound-3 DMA1FRM N. A. N. A. Patented [3]
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5 Discontinued Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
ISIS 3521 DMZFS69 N. A. N. A. Discontinued in Phase 2 [4]
Acteoside DM0YHKB Nephritis GB40 Terminated [5]
BALANOL DMDLN9E N. A. N. A. Terminated [6]
LY-317644 DMM20PI N. A. N. A. Terminated [7]
RO-320432 DMFZ1YW N. A. N. A. Terminated [8]
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39 Investigative Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
(-)-Cercosporamide DMJ249P Discovery agent N.A. Investigative [9]
1,2-dioctanoyl-sn-glycerol DMEAB03 Discovery agent N.A. Investigative [10]
2,3,3-Triphenyl-acrylonitrile DM7H34U Discovery agent N.A. Investigative [11]
2-(4-Hydroxy-phenyl)-3,3-diphenyl-acrylonitrile DMNGW1A Discovery agent N.A. Investigative [11]
3,3-Bis-(4-hydroxy-phenyl)-2-phenyl-acrylonitrile DMO51QG Discovery agent N.A. Investigative [11]
3,3-Bis-(4-methoxy-phenyl)-2-phenyl-acrylonitrile DMZPYN2 Discovery agent N.A. Investigative [11]
3,4-di-(4-methoxyphenyl)-1H-pyrrole-2,5-dione DMDO175 Discovery agent N.A. Investigative [12]
3,4-diphenyl-1H-pyrrole-2,5-dione DMPK6YT Discovery agent N.A. Investigative [12]
3-(1H-Indol-3-yl)-4-phenylamino-pyrrole-2,5-dione DMP0RYB Discovery agent N.A. Investigative [13]
3-(4-Hydroxy-phenyl)-2,3-diphenyl-acrylonitrile DME5238 Discovery agent N.A. Investigative [11]
3-(4-methoxyphenyl)-4-phenyl-1H-pyrrole-2,5-dione DMGC7RY Discovery agent N.A. Investigative [12]
3-(indole-3-yl)-4-phenyl-1H-pyrrole-2,5-dione DM3EV9N Discovery agent N.A. Investigative [12]
4,5,6,7-tetrabromo-1H-benzo[d][1,2,3]triazole DMN9YOB Discovery agent N.A. Investigative [14]
4-cycloheptyliden(4-hydroxyphenyl)methylphenol DM4LIUC Discovery agent N.A. Investigative [11]
4-cyclohexyliden(4-hydroxyphenyl)methylphenol DM8BLK2 Discovery agent N.A. Investigative [11]
4-cyclopentyliden(4-hydroxyphenyl)methylphenol DM7LN53 Discovery agent N.A. Investigative [11]
4-[1-(4-hydroxyphenyl)-3-methyl-1-butenyl]phenol DM8IYG1 Discovery agent N.A. Investigative [11]
CALCEOLARIOSIDE A DM6NPUM Discovery agent N.A. Investigative [5]
CALCEOLARIOSIDE B DMEAUK5 Discovery agent N.A. Investigative [5]
CI-1040 DMF3DZX Discovery agent N.A. Investigative [15]
Diheptan-3-yl 5-(hydroxymethyl)isophthalate DMBAY7P Discovery agent N.A. Investigative [10]
Dihexan-3-yl 5-(hydroxymethyl)isophthalate DM8TBQ9 Discovery agent N.A. Investigative [10]
FORSYTHIASIDE DMPC568 Discovery agent N.A. Investigative [5]
Go 6983 DMKVTZN Discovery agent N.A. Investigative [16]
KN-62 DMLZ89P Discovery agent N.A. Investigative [15]
KT-5720 DM9J50F Discovery agent N.A. Investigative [15]
LEUCOSCEPTOSIDE A DM6W27F Discovery agent N.A. Investigative [5]
LY-326449 DMN53M4 Discovery agent N.A. Investigative [17]
Plantainoside D DMWHNZ4 Discovery agent N.A. Investigative [5]
PROSTRATIN DM1HMJ5 Human immunodeficiency virus infection 1C62 Investigative [18]
PUNICAFOLIN DM7CWQY Discovery agent N.A. Investigative [19]
RO-316233 DMAGLPW Discovery agent N.A. Investigative [20]
Ro-32-0557 DMPVKEA Discovery agent N.A. Investigative [8]
Ro31-8220 DMDJLF0 Discovery agent N.A. Investigative [15]
STAUROSPORINONE DMU2H4K Discovery agent N.A. Investigative [15]
TANNIN DMTFHRI Discovery agent N.A. Investigative [19]
[2,2':5',2'']Terthiophen-4-yl-methanol DMRQC1F Discovery agent N.A. Investigative [21]
[2,2':5',2'']Terthiophene-4,5''-dicarbaldehyde DMWDNLI Discovery agent N.A. Investigative [21]
[2,2':5',2'']Terthiophene-4-carbaldehyde DM2S5EJ Discovery agent N.A. Investigative [21]
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⏷ Show the Full List of 39 Investigative Drug(s)
Molecule Interaction Atlas

References

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2 Emerging drugs for psoriasis. Expert Opin Emerg Drugs. 2009 Mar;14(1):145-63.
3 Cancer stem cell (CSC) inhibitors: a review of recent patents (2012-2015).Expert Opin Ther Pat. 2017 Jul;27(7):753-761.
4 Phase II study of PKC-alpha antisense oligonucleotide aprinocarsen in combination with gemcitabine and carboplatin in patients with advanced non-small cell lung cancer.Lung Cancer.2006 May;52(2):173-80.
5 Phenylethanoid glycosides from Digitalis purpurea and Penstemon linarioides with PKCalpha-inhibitory activity. J Nat Prod. 1998 Nov;61(11):1410-2.
6 Evaluation of differential hypoxic cytotoxicity and electrochemical studies of nitro 5-deazaflavins, Bioorg. Med. Chem. Lett. 5(18):2155-2160 (1995).
7 Synthesis of bisindolylmaleimide macrocycles, Bioorg. Med. Chem. Lett. 5(18):2093-2096 (1995).
8 Bisindolylmaleimide inhibitors of protein kinase C. Further conformational restriction of a tertiary amine side chain, Bioorg. Med. Chem. Lett. 4(11):1303-1308 (1994).
9 (-)-Cercosporamide derivatives as novel antihyperglycemic agents. Bioorg Med Chem Lett. 2009 Feb 1;19(3):724-6.
10 Design, synthesis, and biological activity of isophthalic acid derivatives targeted to the C1 domain of protein kinase C. J Med Chem. 2009 Jul 9;52(13):3969-81.
11 Multivariate analysis by the minimum spanning tree method of the structural determinants of diphenylethylenes and triphenylacrylonitriles implicate... J Med Chem. 1992 Feb 7;35(3):573-83.
12 Design, synthesis, and biological evaluation of 3,4-diarylmaleimides as angiogenesis inhibitors. J Med Chem. 2006 Feb 23;49(4):1271-81.
13 Synthesis of anilino-monoindolylmaleimides as potent and selective PKCbeta inhibitors. Bioorg Med Chem Lett. 2004 Oct 18;14(20):5171-4.
14 Optimization of protein kinase CK2 inhibitors derived from 4,5,6,7-tetrabromobenzimidazole. J Med Chem. 2004 Dec 2;47(25):6239-47.
15 Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105.
16 Inhibition of protein kinase C mu by various inhibitors. Differentiation from protein kinase c isoenzymes. FEBS Lett. 1996 Aug 26;392(2):77-80.
17 (S)-13-[(dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16, 21-dimetheno-1H, 13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene-1,3(2H... J Med Chem. 1996 Jul 5;39(14):2664-71.
18 A nonpromoting phorbol from the samoan medicinal plant Homalanthus nutans inhibits cell killing by HIV-1. J Med Chem. 1992 May 29;35(11):1978-86.
19 Tannins as selective inhibitors of protein kinase C, Bioorg. Med. Chem. Lett. 2(3):239-244 (1992).
20 Inhibitors of protein kinase C. 1. 2,3-Bisarylmaleimides. J Med Chem. 1992 Jan;35(1):177-84.
21 Novel protein kinase C inhibitors: synthesis and PKC inhibition of beta-substituted polythiophene derivatives. Bioorg Med Chem Lett. 1999 Aug 2;9(15):2279-82.