Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTFZDNP)

• DTT Name: Activation B7-1 antigen (CD80) DTT Info
• Gene Name: CD80

Molecule-Related Drug & Molecule List

1 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Abatacept	DMSA8RU	Alopecia areata	ED70.2	Approved	[1]

5 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
RhuDex	DMGM1IR	Rheumatoid arthritis	FA20	Phase 2a	[2]
Galiximab	DMTXCUS	Lymphoma	2A80-2A86	Phase 2	[3]
HS-110	DML4RCG	Non-small-cell lung cancer	2C25.Y	Phase 2	[4]
CAR-T cells targeting CD80/86	DM6Z7AD	Solid tumour/cancer	2A00-2F9Z	Phase 1	[5]
MAXY-4	DMMP7XG	Autoimmune diabetes	5A10	Phase 1	[6]

1 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tolerimab	DMZKIE0	Transplant rejection	NE84	Terminated	[7]

References

• [1] Selective modulation of T-cell co-stimulation: a novel mode of action for the treatment of rheumatoid arthritis. Clin Exp Rheumatol. 2009 May-Jun;27(3):510-8.
• [2] A phase 1 study of AS1409, a novel antibody-cytokine fusion protein, in patients with malignant melanoma or renal cell carcinoma. Clin Cancer Res. 2011 Apr 1;17(7):1998-2005.
• [3] Phase I/II study of galiximab, an anti-CD80 antibody, for relapsed or refractory follicular lymphoma. J Clin Oncol. 2005 Jul 1;23(19):4390-8.
• [4] Clinical pipeline report, company report or official report of Heat Biologics.
• [5] ClinicalTrials.gov (NCT03198052) HER2/Mesothelin/Lewis-Y/PSCA/MUC1/PD-L1/CD80/86-CAR-T Cells Immunotherapy Against Cancers
• [6] Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4. Science. 2011 Apr 29;332(6029):600-3.
• [7] US patent application no. 2004,0171,123, Albumin fusion proteins.