General Information of DTT (ID: TTG043C)

DTT Name Tumor necrosis factor receptor type I (TNF-R1) DTT Info
Gene Name TNFRSF1A

Molecule-Related Drug & Molecule List

Molecule-Related Drug List
Molecule Type:
DTT
DTP
DME
Drug Status:
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
4 Clinical Trial Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
VB-111 DMX04CA Malignant glioma 2A00.0 Phase 3 [1]
Drug 2862277 DM8WU3O Acute lung injury NB32.3 Phase 2 [2]
AVX-470 DMAKD0I Inflammatory bowel disease DD72 Phase 1 [3]
GSK1995057 DMC14KV Adult respiratory distress syndrome CB00 Phase 1 [4]
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1 Discontinued Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
Anti-IFN gamma DMXI185 Alopecia ED70 Terminated [3]
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9 Investigative Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
ADS-0101 DMP7IS0 Chronic obstructive pulmonary disease CA22 Investigative [2]
ALF-421 DM53KRA Acute liver failure DB91 Investigative [3]
Anti-TNF human mabs DMYKTF6 Autoimmune diabetes 5A10 Investigative [3]
NM-2014 DM6RA20 Rheumatoid arthritis FA20 Investigative [2]
NM-9405 DMKMBSJ Rheumatoid arthritis FA20 Investigative [2]
Recombinant human TNF receptor DMLYQWV Arthritis FA20 Investigative [3]
TNFcept DMAGI7K Rheumatoid arthritis FA20 Investigative [3]
TNFmab DM4T0ZF Rheumatoid arthritis FA20 Investigative [3]
TNFR1 NAM DMPTQEG Multiple sclerosis 8A40 Investigative [2]
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⏷ Show the Full List of 9 Investigative Drug(s)
Molecule Interaction Atlas

References

1 Phase I dose-escalation study of VB-111, an antiangiogenic virotherapy, in patients with advanced solid tumors.Clin Cancer Res.2013 Jul 15;19(14):3996-4007.
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1870).
3 Secretion of a TNFR:Fc fusion protein following pulmonary administration of pseudotyped adeno-associated virus vectors. J Virol. 2004 Nov;78(22):12355-65.
4 Autoantibodies to variable heavy (VH) chain Ig sequences in humans impact the safety and clinical pharmacology of a VH domain antibody antagonist of TNF-alpha receptor 1. J Clin Immunol. 2013 Oct;33(7):1192-203.