General Information of DTT (ID: TTGA1IV)

DTT Name Matrix metalloproteinase-8 (MMP-8) DTT Info
Gene Name MMP8

Molecule-Related Drug & Molecule List

Molecule-Related Drug List
Molecule Type:
DTT
DTP
DME
Drug Status:
Discontinued Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
1 Clinical Trial Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
CIPEMASTAT DM803GL Rheumatoid arthritis FA20 Phase 3 [1]
------------------------------------------------------------------------------------
3 Discontinued Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
GM6001 DM7V9CT Corneal ulcer 9A76 Discontinued in Phase 2 [2]
BB-1101 DM7GH5Z Multiple sclerosis 8A40 Terminated [3]
SC-44463 DMBPNKT N. A. N. A. Terminated [4]
------------------------------------------------------------------------------------
19 Investigative Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
1-Hydroxyamine-2-Isobutylmalonic Acid DM6FLXW Discovery agent N.A. Investigative [5]
2-(biphenyl-4-ylsulfonamido)pentanedioic acid DMH3YBR Discovery agent N.A. Investigative [6]
2-(Biphenyl-4-ylsulfonyl)N-hydroxybenzamide DMCNV5J Discovery agent N.A. Investigative [7]
2-HYDROXYCARBAMOYL-4-METHYL-PENTANOIC ACID DMOT6V7 Discovery agent N.A. Investigative [8]
2-Thiomethyl-3-Phenylpropanoic Acid DMCEK6N Discovery agent N.A. Investigative [5]
3-(4-Methoxy-benzenesulfonyl)-cyclohexanethiol DM206M1 Discovery agent N.A. Investigative [9]
3-(4-Methoxy-benzenesulfonyl)-propane-1-thiol DM7B1VT Discovery agent N.A. Investigative [9]
3-(4-Phenoxy-benzenesulfonyl)-cyclohexanethiol DMBKDZ3 Discovery agent N.A. Investigative [9]
3-(4-Phenoxy-benzenesulfonyl)-propane-1-thiol DM2HBGL Discovery agent N.A. Investigative [9]
3-AMINO-AZACYCLOTRIDECAN-2-ONE DM5073T Discovery agent N.A. Investigative [8]
4-amino-3-(4-(hexyloxy)phenyl)-4-oxobutanoic acid DMGI0YV Discovery agent N.A. Investigative [6]
Glycinamid DMTCEFV Discovery agent N.A. Investigative [5]
IK-862 DMJA4UE Discovery agent N.A. Investigative [10]
METHYLAMINO-PHENYLALANYL-LEUCYL-HYDROXAMIC ACID DM9JECY Discovery agent N.A. Investigative [8]
MMI270 DM38N2K Discovery agent N.A. Investigative [11]
N-Hydroxy-2-(4-phenoxy-benzenesulfonyl)benzamide DM4VADN Discovery agent N.A. Investigative [7]
Ro-37-9790 DM83QMZ Discovery agent N.A. Investigative [12]
SL422 DM3I2US Discovery agent N.A. Investigative [13]
[2-(Biphenyl-4-sulfonyl)phenyl]acetic Acid DM37C25 Discovery agent N.A. Investigative [7]
------------------------------------------------------------------------------------
⏷ Show the Full List of 19 Investigative Drug(s)
Molecule Interaction Atlas

References

1 Matrix metalloproteinase inhibition lowers mortality and brain injury in experimental pneumococcal meningitis. Infect Immun. 2014 Apr;82(4):1710-8.
2 Hydroxamate inhibitors of human gelatinase B (92 kDa), Bioorg. Med. Chem. Lett. 5(4):349-352 (1995).
3 New alpha-substituted succinate-based hydroxamic acids as TNFalpha convertase inhibitors. J Med Chem. 1999 Nov 18;42(23):4890-908.
4 Design and synthesis of a series of (2R)-N(4)-hydroxy-2-(3-hydroxybenzyl)-N(1)- [(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]butanediamide derivati... J Med Chem. 2001 Oct 11;44(21):3347-50.
5 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
6 Ranking the selectivity of PubChem screening hits by activity-based protein profiling: MMP13 as a case study. Bioorg Med Chem. 2009 Feb 1;17(3):1101-8.
7 Design, synthesis, biological evaluation, and NMR studies of a new series of arylsulfones as selective and potent matrix metalloproteinase-12 inhib... J Med Chem. 2009 Oct 22;52(20):6347-61.
8 The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
9 Synthesis and identification of conformationally constrained selective MMP inhibitors. Bioorg Med Chem Lett. 1999 Jul 5;9(13):1757-60.
10 Discovery of gamma-lactam hydroxamic acids as selective inhibitors of tumor necrosis factor alpha converting enzyme: design, synthesis, and structu... J Med Chem. 2002 Nov 7;45(23):4954-7.
11 Design, synthesis, and biological evaluation of potent thiazine- and thiazepine-based matrix metalloproteinase inhibitors. J Med Chem. 1999 Nov 4;42(22):4547-62.
12 11,21-Bisphenyl-19-norpregnane derivatives are selective antiglucocorticoids, Bioorg. Med. Chem. Lett. 7(17):2299-2302 (1997).
13 Design, synthesis, and structure-activity relationships of macrocyclic hydroxamic acids that inhibit tumor necrosis factor alpha release in vitro and in vivo. J Med Chem. 2001 Aug 2;44(16):2636-60.