Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTHGL48)

• DTT Name: AP endonuclease 1 (APEX1) DTT Info
• Gene Name: APEX1

Molecule-Related Drug & Molecule List

2 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
APX3330	DMU6NBO	Diabetic retinopathy	9B71.0	Phase 2	[1]
APX-3330	DMXIMQT	Solid tumour/cancer	2A00-2F9Z	Phase 1	[2]

3 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
1,3-bis(1,3-benzothiazol-2-ylthio)acetone	DMP86R3	Glioma	2A00.0	Investigative	[3]
3-benzofuran-2-yl-2-benzothiazol-2-yl-3-oxo-propanenitrile	DMWLIK1	Glioma	2A00.0	Investigative	[3]
5-fluoro-1H-indole-2-carboxylic acid	DM9U1HV	Glioma	2A00.0	Investigative	[3]

References

• [1] Exploiting the Ref-1-APE1 node in cancer signaling and other diseases: from bench to clinic. NPJ Precis Oncol. 2017;1:19.
• [2] Inhibition of APE1/Ref-1 redox activity with APX3330 blocks retinal angiogenesis in vitro and in vivo. Vision Res. 2011 Jan;51(1):93-100.
• [3] Development and evaluation of human AP endonuclease inhibitors in melanoma and glioma cell lines. Br J Cancer. 2011 Feb 15;104(4):653-63.