Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTHQENC)

• DTT Name: Phosphodiesterase 1 (PDE1) DTT Info
• Gene Name: PDE1

Molecule-Related Drug & Molecule List

1 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Vinpocetine	DMVN2E6	Ischemic stroke	8B11.5Z	Approved	[1]

1 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ITI-214	DM08TH3	Parkinson disease	8A00.0	Phase 1/2	[2]

2 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BIBW-22	DMXIH3Q	Solid tumour/cancer	2A00-2F9Z	Terminated	[3]
ZAPRINAST	DMGH3T5	N. A.	N. A.	Terminated	[4]

3 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BUFROLIN	DM61F5W	Discovery agent	N.A.	Investigative	[5]
isobutylmethylxanthine	DM46F5X	Discovery agent	N.A.	Investigative	[5]
S,S-(2-Hydroxyethyl)Thiocysteine	DMLPAD8	Discovery agent	N.A.	Investigative	[6]

References

• [1] Effects of phosphodiesterase inhibitors on contraction induced by endothelin-1 of isolated human prostatic tissue. Urology. 2009 Jun;73(6):1397-401.
• [2] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [3] BIBW22 BS, potent multidrug resistance-reversing agent, binds directly to P-glycoprotein and accumulates in drug-resistant cells. Mol Pharmacol. 1996 Sep;50(3):482-92.
• [4] The next generation of phosphodiesterase inhibitors: structural clues to ligand and substrate selectivity of phosphodiesterases. J Med Chem. 2005 May 19;48(10):3449-62.
• [5] A new generation of phosphodiesterase inhibitors: multiple molecular forms of phosphodiesterase and the potential for drug selectivity. J Med Chem. 1985 May;28(5):537-45.
• [6] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.