Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTHWMFZ)

• DTT Name: Fatty acid-binding protein 4 (FABP4) DTT Info
• Gene Name: FABP4

Molecule-Related Drug & Molecule List

25 Patented Agent(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PMID27109571-Compound-10	DMW60HU	N. A.	N. A.	Patented	[1]
PMID27109571-Compound-11	DMMI4KQ	N. A.	N. A.	Patented	[1]
PMID27109571-Compound-12	DM6HWBK	N. A.	N. A.	Patented	[1]
PMID27109571-Compound-13	DMUKOGJ	N. A.	N. A.	Patented	[1]
PMID27109571-Compound-14	DMVY6B9	N. A.	N. A.	Patented	[1]
PMID27109571-Compound-15	DMUR3FY	N. A.	N. A.	Patented	[1]
PMID27109571-Compound-16	DMZI25U	N. A.	N. A.	Patented	[1]
PMID27109571-Compound-17	DMBETU6	N. A.	N. A.	Patented	[1]
PMID27109571-Compound-18	DM4S5ME	N. A.	N. A.	Patented	[1]
PMID27109571-Compound-19	DMIJGLB	N. A.	N. A.	Patented	[1]
PMID27109571-Compound-20	DMQU9XP	N. A.	N. A.	Patented	[1]
PMID27109571-Compound-21	DM0R5Y8	N. A.	N. A.	Patented	[1]
PMID27109571-Compound-22	DMC52VP	N. A.	N. A.	Patented	[1]
PMID27109571-Compound-23	DML49UI	N. A.	N. A.	Patented	[1]
PMID27109571-Compound-24	DMPHTC0	N. A.	N. A.	Patented	[1]
PMID27109571-Compound-25	DM435GR	N. A.	N. A.	Patented	[1]
PMID27109571-Compound-26	DMJCL53	N. A.	N. A.	Patented	[1]
PMID27109571-Compound-27	DMXRTH4	N. A.	N. A.	Patented	[1]
PMID27109571-Compound-28	DMTZVY3	N. A.	N. A.	Patented	[1]
PMID27109571-Compound-29	DMDMEHQ	N. A.	N. A.	Patented	[1]
PMID27109571-Compound-30	DM24FSP	N. A.	N. A.	Patented	[1]
PMID27109571-Compound-31	DMU690T	N. A.	N. A.	Patented	[1]
PMID27109571-Compound-7	DM8GYCD	N. A.	N. A.	Patented	[1]
PMID27109571-Compound-8	DMTKFX7	N. A.	N. A.	Patented	[1]
PMID27109571-Compound-9	DMWM03O	N. A.	N. A.	Patented	[1]

15 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
1-benzyl-2,3-dimethyl-1H-indole-7-carboxylic acid	DMQFS2D	Discovery agent	N.A.	Investigative	[2]
2-(2,3-bis(2-chlorobenzyloxy)phenyl)acetic acid	DM1T8IP	Discovery agent	N.A.	Investigative	[3]
2-(3-Methyl-indole-1-sulfonyl)-benzoic acid	DMFOA6R	Discovery agent	N.A.	Investigative	[4]
2-(4-Fluoro-indole-1-sulfonyl)-benzoic acid	DMKFIEY	Discovery agent	N.A.	Investigative	[4]
2-(4-Methyl-indole-1-sulfonyl)-benzoic acid	DM943YL	Discovery agent	N.A.	Investigative	[4]
2-(5-Bromo-indole-1-sulfonyl)-benzoic acid	DMXRYDL	Discovery agent	N.A.	Investigative	[4]
2-(6-Methoxy-indole-1-sulfonyl)-benzoic acid	DM41UYN	Discovery agent	N.A.	Investigative	[4]
2-(Carbazole-9-sulfonyl)-benzoic acid	DMA6P4J	Discovery agent	N.A.	Investigative	[4]
3-Carbazol-9-yl-propionic acid	DMHUBT5	Discovery agent	N.A.	Investigative	[4]
4-Carbazol-9-yl-butyric acid	DM74GWO	Discovery agent	N.A.	Investigative	[4]
5-Carbazol-9-yl-pentanoic acid	DM04WVH	Discovery agent	N.A.	Investigative	[4]
BMS-480404	DMTPNI4	Discovery agent	N.A.	Investigative	[3]
Hexadecanoic acid	DMWUXDZ	Discovery agent	N.A.	Investigative	[4]
LINOLEIC ACID	DMDGPY9	Discovery agent	N.A.	Investigative	[5]
OLEIC ACID	DM54O1Z	Discovery agent	N.A.	Investigative	[5]

References

• [1] Fatty acid binding protein (FABP) inhibitors: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):767-76.
• [2] N-Benzyl-indolo carboxylic acids: Design and synthesis of potent and selective adipocyte fatty-acid binding protein (A-FABP) inhibitors. Bioorg Med Chem Lett. 2009 Mar 15;19(6):1745-8.
• [3] NMR structure of a potent small molecule inhibitor bound to human keratinocyte fatty acid-binding protein. J Med Chem. 2006 Aug 10;49(16):5013-7.
• [4] Discovery of inhibitors of human adipocyte fatty acid-binding protein, a potential type 2 diabetes target. Bioorg Med Chem Lett. 2004 Sep 6;14(17):4445-8.
• [5] Discovery of highly selective inhibitors of human fatty acid binding protein 4 (FABP4) by virtual screening. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3675-9.