Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTICX3S)

• DTT Name: Bacterial UDP-N-acetylglucosamine carboxyvinyltransferase (Bact murA) DTT Info
• Gene Name: Bact murA

Molecule-Related Drug & Molecule List

1 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fosfomycin	DMVGPMX	Bacterial infection	1A00-1C4Z	Approved	[1]

9 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aminomethylcyclohexane	DMNX9FC	Discovery agent	N.A.	Investigative	[2]
CNICIN	DMEVM0J	Discovery agent	N.A.	Investigative	[3]
Cyclohexylammonium Ion	DMYQH2N	Discovery agent	N.A.	Investigative	[2]
CYNAROPICRIN	DMG0PHU	Discovery agent	N.A.	Investigative	[3]
EUPATORIOPICRIN	DM068CY	Discovery agent	N.A.	Investigative	[3]
L-Iso-Aspartate	DM26AB4	Discovery agent	N.A.	Investigative	[2]
RWJ-140998	DMP7SI9	Gram-positive bacterial infection	1B74-1G40	Investigative	[4]
RWJ-3981	DMBVLCQ	Gram-positive bacterial infection	1B74-1G40	Investigative	[4]
Uridine-Diphosphate-N-Acetylglucosamine	DMEQSTP	Discovery agent	N.A.	Investigative	[5]

References

• [1] Evidence that the fosfomycin target Cys115 in UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) is essential for product release. J Biol Chem. 2005 Feb 4;280(5):3757-63.
• [2] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
• [3] Sesquiterpene lactones are potent and irreversible inhibitors of the antibacterial target enzyme MurA. Bioorg Med Chem Lett. 2006 Nov 1;16(21):5605-9.
• [4] Emerging drugs for bacterial urinary tract infections. Expert Opin Emerg Drugs. 2005 May;10(2):275-98.
• [5] DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41.