Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTIG65Q)

• DTT Name: Voltage-gated sodium channel (Nav) DTT Info
• Gene Name: Nav

Molecule-Related Drug & Molecule List

8 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cenobamate	DM8KLU9	Complex partial seizure	8A68.0	Approved	[1]
Eslicarbazepine	DMZREFQ	Seizure disorder	8A6Z	Approved	[2]
Flecainide	DMSQDLE	Tachyarrhythmias	BC71	Approved	[3]
Lacosamide	DMVM6QR	Convulsion	8A68.Z	Approved	[2]
Procainamide	DMNMXR8	Ventricular arrhythmias	BC71	Approved	[3]
Propafenone	DMPIBJK	Tachyarrhythmias	BC71	Approved	[3]
Tetrodotoxin	DMWMPRG	Bacterial infection	1A00-1C4Z	Approved	[2]
Tocainide	DMYNMDP	Ventricular arrhythmias	BC71	Approved	[3]

1 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Evenamide	DMWB94K	Schizophrenia	6A20	Phase 2	[4]

1 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Barucainide	DMTMS3L	Heart arrhythmia	BC65	Terminated	[5]

References

• [1] Effects of cenobamate (YKP3089), a newly developed anti-epileptic drug, on voltage-gated sodium channels in rat hippocampal CA3 neurons. Eur J Pharmacol. 2019 Jul 15;855:175-182.
• [2] Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357.
• [3] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
• [4] Clinical pipeline report, company report or official report of Newron Pharmaceuticals.
• [5] Barucainide, a novel class Ib antiarrhythmic agent with a slow kinetic property: electrophysiologic observations in isolated canine and rabbit cardiac muscle. Am Heart J. 1990 May;119(5):1050-60.