Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTIQSVM)

• DTT Name: Integrin alpha-V/beta-6 (ITGAV/B6) DTT Info
• Gene Name: ITGAV-ITGB6

Molecule-Related Drug & Molecule List

2 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PLN-74809	DMQDN46	Idiopathic pulmonary fibrosis	CB03.4	Phase 2	[1]
STX-100	DMR9COG	Idiopathic pulmonary fibrosis	CB03.4	Phase 2	[2]

1 Preclinical Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
CWHM-12	DM8YUJT	Hepatic fibrosis	DB93.0	Preclinical	[3]

References

• [1] Dual inhibition of alpha(v)beta(6) and alpha(v)beta(1) reduces fibrogenesis in lung tissue explants from patients with IPF. Respir Res. 2021 Oct 19;22(1):265.
• [2] Integrin-mediated regulation of TGFbeta in fibrosis. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease Volume 1832, Issue 7, July 2013, Pages 891-896.
• [3] Targeting of alphav integrin identifies a core molecular pathway that regulates fibrosis in several organs. Nat Med. 2013 Dec;19(12):1617-24.