Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTJ2HKA)

DTT Name	Long transient receptor potential channel 4 (TRPM4) DTT Info
UniProt ID	TRPM4_HUMAN
Gene Name	TRPM4

Molecule-Related Drug & Molecule List

Molecule-Related Drug List

Molecule Type:

DTT

DTP

DME

Drug Status:

Investigative Drug(s)

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6 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
9-phenanthrol	DMJFBQ1	Discovery agent	N.A.	Investigative	[1]
adenosine diphosphate	DMFUHKP	N. A.	N. A.	Investigative	[2]
AMP-PNP	DMTOK1D	Discovery agent	N.A.	Investigative	[2]
BTP2	DMNM63G	Discovery agent	N.A.	Investigative	[3]
decavanadate	DMLT1N3	Discovery agent	N.A.	Investigative	[4]
PIP2	DMOZV7N	Discovery agent	N.A.	Investigative	[5]
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Molecule Interaction Atlas

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References

1	9-phenanthrol inhibits human TRPM4 but not TRPM5 cationic channels. Br J Pharmacol. 2008 Apr;153(8):1697-705.
2	Intracellular nucleotides and polyamines inhibit the Ca2+-activated cation channel TRPM4b. Pflugers Arch. 2004 Apr;448(1):70-5.
3	A pyrazole derivative potently inhibits lymphocyte Ca2+ influx and cytokine production by facilitating transient receptor potential melastatin 4 ch... Mol Pharmacol. 2006 Apr;69(4):1413-20.
4	Decavanadate modulates gating of TRPM4 cation channels. J Physiol. 2004 Nov 1;560(Pt 3):753-65.
5	Phosphatidylinositol 4,5-bisphosphate rescues TRPM4 channels from desensitization. J Biol Chem. 2005 Nov 25;280(47):39185-92.