Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTJME02)

• DTT Name: Atrial natriuretic peptide receptor A (NPR1) DTT Info
• Gene Name: NPR1

Molecule-Related Drug & Molecule List

1 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nesiritide	DMFOIA8	Congestive heart failure	BD10	Approved	[1]

4 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ularitide	DM90AG2	Acute heart failure	BD10-BD13	Phase 3	[2]
Ataciguat	DM35KDA	Neuropathic pain	8E43.0	Phase 2	[3]
Cenderitide	DMCT8EY	Heart disease	BA41-BA42	Phase 2	[4]
PL-3994	DMHUCQS	Asthma	CA23	Phase 2	[5]

References

• [1] The efficacy and safety of B-type natriuretic peptide (nesiritide) in patients with renal insufficiency and acutely decompensated congestive heart failure. Nephrol Dial Transplant. 2004 Feb;19(2):391-9.
• [2] Ularitide for the treatment of acute decompensated heart failure: from preclinical to clinical studies. Eur Heart J. 2015 Mar 21;36(12):715-23.
• [3] Pharma & Vaccines. Product Development Pipeline. April 29 2009.
• [4] 2011 Pipeline of Nile Therapeutics.
• [5] In vitro and in vivo pharmacological profile of PL-3994, a novel cyclic peptide (Hept-cyclo(Cys-His-Phe-d-Ala-Gly-Arg-d-Nle-Asp-Arg-Ile-Ser-Cys)-Tyr-[Arg mimetic]-NH2) natriuretic peptide receptor-A agonist that is resistant to neutral endopeptidase and acts as a bronchodilator. Pulm Pharmacol Ther. 2013 April; 26(2): 229-238.