Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTJQFBG)

• DTT Name: HIF-prolyl hydroxylase (HPH) DTT Info
• Gene Name: HPH

Molecule-Related Drug & Molecule List

1 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclopirox	DMN5T2A	Cutaneous candidiasis	1F23.14	Approved	[1]

6 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AKB-6548	DM2EJM3	Anaemia	3A90	Phase 3	[2]
BAY 853934	DM407I6	Anaemia	3A90	Phase 3	[3]
JTZ-951	DM8FSPV	Anaemia	3A90	Phase 3	[4]
FG-2216	DM7RYL4	Kidney disease	GC2Z	Phase 2	[5]
DS-1093	DM42KZW	Anemia	3A00-3A9Z	Phase 1	[6]
ZYAN1	DM796RI	Anaemia	3A90	Phase 1	[7]

1 Preclinical Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
JNJ-42905343	DMCNBHY	Anaemia	3A90	Preclinical	[8]

References

• [1] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
• [2] DOI: 10.1038/nrd4422
• [3] Discovery of Molidustat (BAY 85-3934): A Small-Molecule Oral HIF-Prolyl Hydroxylase (HIF-PH) Inhibitor for the Treatment of Renal Anemia. ChemMedChem. 2018 May 23;13(10):988-1003.
• [4] DOI: 10.1038/nrneph.2015.82
• [5] Inhibition of Prolyl Hydroxylases Increases Erythropoietin Production in ESRD
• [6] Company report (Daiichisankyo)
• [7] Pharmacological Characterization of ZYAN1, a Novel Prolyl Hydroxylase Inhibitor for the Treatment of Anemia. Drug Res (Stuttg). 2016 Feb;66(2):107-12.
• [8] Prolyl hydroxylase inhibition corrects functional iron deficiency and inflammation-induced anaemia in rats. Br J Pharmacol. 2015 Aug;172(16):4078-88.