Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTKBM7V)

• DTT Name: ATM serine/threonine kinase (ATM) DTT Info
• Gene Name: ATM

Molecule-Related Drug & Molecule List

4 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AZD0156	DMWCJEU	Solid tumour/cancer	2A00-2F9Z	Phase 1	[1]
AZD1390	DMYBX4N	Recurrent glioblastoma	2A00.00	Phase 1	[1]
M3541	DMG98QO	Solid tumour/cancer	2A00-2F9Z	Phase 1	[1]
KU-60019	DMWA5XP	Non-small-cell lung cancer	2C25.Y	Clinical trial	[2]

1 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
CGK733	DM8OAN9	Discovery agent	N.A.	Investigative	[3]

References

• [1] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [2] Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion. Mol Cancer Ther. 2009 Oct;8(10):2894-902.
• [3] Small molecule-based reversible reprogramming of cellular lifespan. Nat Chem Biol. 2006 Jul;2(7):369-74.