General Information of DTT (ID: TTKFVXR)

DTT Name Renal carcinoma antigen NY-REN-64 (IRAK-4) DTT Info
Gene Name IRAK4

Molecule-Related Drug & Molecule List

Molecule-Related Drug List
Molecule Type:
DTT
DTP
DME
Drug Status:
Clinical Trial Drug(s)
Patented Agent(s)
Investigative Drug(s)
6 Clinical Trial Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
GS-5718 DMRKU0L Rheumatoid arthritis FA20 Phase 2 [1]
Zabedosertib DMEZGWP Atopic dermatitis EA80 Phase 2 [2]
AZD6793 DM5GRZV Inflammation 1A00-CA43.1 Phase 1 [3]
BAY1834845 DM8V62T Psoriasis vulgaris EA90 Phase 1 [4]
CA-4948 DMWV8C6 Lymphoma 2A80-2A86 Phase 1 [5]
SAR444656 DMIF2OL Atopic dermatitis EA80 Phase 1 [6]
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⏷ Show the Full List of 6 Clinical Trial Drug(s)
21 Patented Agent(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amidopyrazole derivative 1 DM5X92S N. A. N. A. Patented [7]
Amidopyrazole derivative 2 DMGO9WY N. A. N. A. Patented [7]
Amidopyrazole derivative 3 DMTHS3L N. A. N. A. Patented [7]
Amidopyrazole derivative 4 DMF6N7Z N. A. N. A. Patented [7]
Amidopyrazole derivative 5 DMJ37V2 N. A. N. A. Patented [7]
Amidopyrazole derivative 6 DMJZ1IG N. A. N. A. Patented [7]
Diaminopyridine analog 4 DMPUH4Z N. A. N. A. Patented [7]
Diaminopyridine analog 5 DM5B0F3 N. A. N. A. Patented [7]
Fused benzoheterocycle amide derivative 1 DMKLO2H N. A. N. A. Patented [7]
Fused benzoheterocycle amide derivative 2 DM9NMHS N. A. N. A. Patented [7]
Indazole amide derivative 1 DMKUT6S N. A. N. A. Patented [7]
Indazole amide derivative 2 DMRPT5O N. A. N. A. Patented [7]
Indazoletriazolephenyl derivative 1 DMHJDU6 N. A. N. A. Patented [7]
Indazoletriazolephenyl derivative 2 DMWZLK6 N. A. N. A. Patented [7]
Macrolactam derivative 1 DM0ON7S N. A. N. A. Patented [7]
Macrolactam derivative 2 DME72VA N. A. N. A. Patented [7]
Macrolactam derivative 3 DMFNGUV N. A. N. A. Patented [7]
Macrolactam derivative 4 DM5AXHF N. A. N. A. Patented [7]
Pyrazole N-1 aryl and heteroaryl derivative 1 DMVX7YT N. A. N. A. Patented [7]
Pyrazolopyrimidine and thienopyrimidine amide derivative 1 DM6TB4Z N. A. N. A. Patented [7]
Pyrazolopyrimidine and thienopyrimidine amide derivative 2 DMFUNH4 N. A. N. A. Patented [7]
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⏷ Show the Full List of 21 Patented Agent(s)
8 Investigative Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
IRAK-1/4 inhibitor DMOQBGP Discovery agent N.A. Investigative [8]
IRAK4 inhibitor 4b DMC80TA Discovery agent N.A. Investigative [9]
IRAK4 inhibitor rac-45 DM1XHNW Discovery agent N.A. Investigative [10]
ND-2110 DMMODRE Discovery agent N.A. Investigative [11]
ND-2158 DMH7GLE Discovery agent N.A. Investigative [11]
PF-05313261 DMOLI1E Inflammation 1A00-CA43.1 Investigative [12]
WO2012007375C1 DMOZATX Discovery agent N.A. Investigative [12]
WO2012007375C7 DMPI2MA Discovery agent N.A. Investigative [12]
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⏷ Show the Full List of 8 Investigative Drug(s)
Molecule Interaction Atlas

References

1 IRAK4 degrader to take on innate immunity. Nat Biotechnol. 2020 Nov;38(11):1221-1223.
2 Oral IRAK4 inhibitor BAY-1834845 prevents acute respiratory distress syndrome. Biomed Pharmacother. 2022 Sep;153:113459.
3 Clinical pipeline report, company report or official report of AstraZeneca
4 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
5 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
6 Clinical pipeline report, company report or official report of Sanofi
7 Inhibitors of interleukin-1 receptor-associated kinase 4 (IRAK4): a patent review (2012-2015).Expert Opin Ther Pat. 2016 Aug;26(8):917-32.
8 Discovery and initial SAR of inhibitors of interleukin-1 receptor-associated kinase-4. Bioorg Med Chem Lett. 2006 Jun 1;16(11):2842-5.
9 IRAK-4 inhibitors. Part 1: a series of amides. Bioorg Med Chem Lett. 2008 Jun 1;18(11):3211-4.
10 IRAK-4 inhibitors. Part III: a series of imidazo[1,2-a]pyridines. Bioorg Med Chem Lett. 2008 Jun 15;18(12):3656-60.
11 Recent advances in the discovery of small molecule inhibitors of interleukin-1 receptor-associated kinase 4 (IRAK4) as a therapeutic target for inflammation and oncology disorders. J Med Chem. 2015 Jan 8;58(1):96-110.
12 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2045).