Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTLDPRG)

• DTT Name: Guanylyl cyclase C (GUCY2C) DTT Info
• Gene Name: GUCY2C

Molecule-Related Drug & Molecule List

3 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Linaclotide	DM4EGV0	Irritable bowel syndrome	DD91.0	Approved	[1]
MD-1100	DM4IAKR	Constipation	DD91.1	Approved	[2]
Plecanatide	DMKEX7O	Chronic idiopathic constipation	DC32	Approved	[3]

3 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
MLN0264	DMI4E9K	Gastrointestinal cancer	2C11	Phase 2	[4]
SP-333	DM2UKJV	Ulcerative colitis	DD71	Phase 2	[5]
PF-07062119	DME3BJL	Solid tumour/cancer	2A00-2F9Z	Phase 1	[6]

References

• [1] Emerging drugs for postoperative ileus. Expert Opin Emerg Drugs. 2007 Nov;12(4):619-26.
• [2] Emerging drugs for irritable bowel syndrome. Expert Opin Emerg Drugs. 2006 May;11(2):293-313.
• [3] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
• [4] J Clin Oncol 31, 2013 (suppl; abstr TPS3646).
• [5] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [6] Discovery and optimization of a novel anti-GUCY2c x CD3 bispecific antibody for the treatment of solid tumors. MAbs. Jan-Dec 2021;13(1):1850395.