Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTLGTKB)

• DTT Name: Interleukin-4 (IL4) DTT Info
• Gene Name: IL4

Molecule-Related Drug & Molecule List

9 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexpramipexole	DM6KXAU	Eosinophilic asthma	CB02.0	Phase 3	[1]
IL-4R	DMYEGRH	N. A.	N. A.	Phase 2	[2]
Pascolizumab	DMU3XJP	Asthma	CA23	Phase 2	[3]
PEGylated pitrakinra	DMBPJ9U	Asthma	CA23	Phase 2	[3]
Romilkimab	DMYEZ5J	Idiopathic pulmonary fibrosis	CB03.4	Phase 2	[4]
SAR-156597	DMUICJD	Idiopathic pulmonary fibrosis	CB03.4	Phase 2	[5]
Tepoxalin	DMVS61L	Asthma	CA23	Phase 2	[6]
PF-07264660	DM0GI2H	Atopic dermatitis	EA80	Phase 1	[7]
PF-07275315	DMHRVUY	Atopic dermatitis	EA80	Phase 1	[7]

References

• [1] Therapeutic strategies for eosinophilic dermatoses. Curr Opin Pharmacol. 2019 Jun;46:29-33.
• [2] Efficacy of soluble IL-4 receptor for the treatment of adults with asthma. J Allergy Clin Immunol. 2001 Jun;107(6):963-70.
• [3] The potential of biologics for the treatment of asthma. Nat Rev Drug Discov. 2012 Dec;11(12):958-72.
• [4] A randomised, double-blind, placebo-controlled, 24-week, phase II, proof-of-concept study of romilkimab (SAR156597) in early diffuse cutaneous systemic sclerosis. Ann Rheum Dis. 2020 Dec;79(12):1600-1607.
• [5] Bispecific antibodies rise again. Nat Rev Drug Discov. 2014 Nov;13(11):799-801.
• [6] Therapeutic interference with interferon-gamma (IFN-gamma) and soluble IL-4 receptor (sIL-4R) in allergic diseases. Behring Inst Mitt. 1995 Jun;(96):118-30.
• [7] Clinical pipeline report, company report or official report of Pfizer