General Information of DTT (ID: TTMF8H9)

DTT Name Plasma kallikrein (KLKB1) DTT Info
Gene Name KLKB1

Molecule-Related Drug & Molecule List

Molecule-Related Drug List
Molecule Type:
DTT
DTP
DME
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
3 Approved Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
Berotralstat DMWA2DZ Hereditary angioedema 4A00.14 Approved [1]
Ecallantide DMOF2C6 Retina venous occlusion 9B74.1 Approved [2]
Lanadelumab DMEH7YU Hereditary angioedema 4A00.14 Approved [3]
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3 Clinical Trial Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
KVD001 DMK4VOU Diabetic macular edema 9B71.02 Phase 2 [4]
KVD824 DM5N4OA Diabetic macular edema 9B71.02 Phase 2 [5]
THR-149 DMW8X05 Diabetic macular edema 9B71.02 Phase 2 [6]
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8 Investigative Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
(3,4-dichlorophenyl)(1H-pyrazol-1-yl)methanone DMNVDLI Discovery agent N.A. Investigative [7]
(3-nitro-1H-pyrazol-1-yl)(p-tolyl)methanone DMT9FZD Discovery agent N.A. Investigative [7]
(3-nitro-1H-pyrazol-1-yl)(phenyl)methanone DMD4Z6H Discovery agent N.A. Investigative [7]
(4-bromo-1H-pyrazol-1-yl)(p-tolyl)methanone DM31OSD Discovery agent N.A. Investigative [7]
1-benzoyl-N-phenyl-1H-pyrazole-3-carboxamide DMG5MNZ Discovery agent N.A. Investigative [7]
D-Pro-Phe-Arg chloromethyl ketone DMRJQ8X Discovery agent N.A. Investigative [8]
ZK-810388 DMNOWAQ Discovery agent N.A. Investigative [9]
ZK-814048 DMCBV5F Discovery agent N.A. Investigative [9]
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⏷ Show the Full List of 8 Investigative Drug(s)
Molecule Interaction Atlas

References

1 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2020
2 Ecallantide (DX-88), a plasma kallikrein inhibitor for the treatment of hereditary angioedema and the prevention of blood loss in on-pump cardiothoracic surgery. Expert Opin Biol Ther. 2008 Aug;8(8):1187-99.
3 2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89.
4 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
5 Clinical pipeline report, company report or official report of KalVista Pharmaceuticals.
6 Clinical pipeline report, company report or official report of Oxurion.
7 N-benzoylpyrazoles are novel small-molecule inhibitors of human neutrophil elastase. J Med Chem. 2007 Oct 4;50(20):4928-38.
8 Novel 3-carboxamide-coumarins as potent and selective FXIIa inhibitors. J Med Chem. 2008 Jun 12;51(11):3077-80.
9 Thiophene-anthranilamides as highly potent and orally available factor Xa inhibitors. J Med Chem. 2007 Jun 28;50(13):2967-80.