Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTMXGCW)

• DTT Name: Adrenergic receptor beta-3 (ADRB3) DTT Info
• Gene Name: ADRB3

Molecule-Related Drug & Molecule List

9 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amosulalol	DML8QSZ	Hypertension	BA00-BA04	Approved	[1]
Bitolterol	DMK6XAV	Chronic obstructive pulmonary disease	CA22	Approved	[2]
Bopindolol	DMIFYLX	Hypertension	BA00-BA04	Approved	[3]
Mepindolol	DMUDWP9	Angina pectoris	BA40	Approved	[4]
Mirabegron	DMS1GYT	Overactive bladder	GC50.0	Approved	[5]
Nipradilol	DMA65ER	Angina pectoris	BA40	Approved	[6]
Rimiterol	DMA47C6	Asthma	CA23	Approved	[7]
Trihexyphenidyl	DMB19L8	Dystonia	8A02	Approved	[8]
Vibegron	DMFR201	Overactive bladder	GC50.0	Approved	[9]

18 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ONO-2506	DMCA2PJ	Stroke	8B20	Phase 2/3	[10]
APD418	DM88IBE	Heart failure with reduced ejection fraction	BD11.2	Phase 2	[11]
ASP-3652	DM4KTN6	Overactive bladder	GC50.0	Phase 2	[12]
AZ-40140	DM9LKYP	Obesity	5B81	Phase 2	[13]
CL-316,243	DMXH1KC	Obesity	5B81	Phase 2	[14]
CP-331684	DMVO5DR	Diabetic complication	5A2Y	Phase 2	[15]
GW-427353	DMBX9C0	Urinary incontinence	MF50.2	Phase 2	[13]
LY-362884	DMD09CT	Obesity	5B81	Phase 2	[13]
LY-377604	DMZCU7I	Obesity	5B81	Phase 2	[16]
N-5984	DMUK6HC	Obesity	5B81	Phase 2	[13]
YM-430	DMKJF6H	Hypertension	BA00-BA04	Phase 2	[17]
ZD2079	DMTYD8Q	Diabetic complication	5A2Y	Phase 2	[18]
QLT-091568	DM2CDLS	Glaucoma/ocular hypertension	9C61	Phase 1/2	[19]
BMS-196085	DMTZ3A6	Diabetic complication	5A2Y	Phase 1	[20]
KUC-7483	DMTFWLE	Overactive bladder	GC50.0	Phase 1	[21]
KUL-7211	DMKFVX5	Neurogenic bladder dysfunction	GC01.4	Phase 1	[22]
Laevo-Bambuterol	DMC0VJF	Asthma	CA23	Phase 1	[23]
ZD7114	DMZQP7N	Diabetic complication	5A2Y	Phase 1	[18]

21 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Epanolol	DML1Y49	Angina pectoris	BA40	Discontinued in Preregistration	[24]
PW-2101	DMD8K3B	Angina pectoris	BA40	Discontinued in Preregistration	[25]
Amibegron	DMPS14M	Major depressive disorder	6A70.3	Discontinued in Phase 3	[26]
Adaprolol maleate-SME	DMTOCV7	Glaucoma/ocular hypertension	9C61	Discontinued in Phase 2	[27]
ALPRENOXIME HYDROCHLORIDE	DMIKLRN	Glaucoma/ocular hypertension	9C61	Discontinued in Phase 2	[28]
OBERADILOL MONOETHYL MALEATE	DMO8PN9	Hypertension	BA00-BA04	Discontinued in Phase 2	[29]
PROXODOLOL	DM8U3R6	Glaucoma/ocular hypertension	9C61	Discontinued in Phase 2	[30]
Rafabegron	DMI1SXB	Type-2 diabetes	5A11	Discontinued in Phase 2	[31]
Tienoxolol	DMLWBYO	Hypertension	BA00-BA04	Discontinued in Phase 2	[32]
NCX 950	DMNXCFZ	Asthma	CA23	Discontinued in Phase 1/2	[33]
MN-246	DM2PUYI	Urinary incontinence	MF50.2	Discontinued in Phase 1	[34]
PAFENOLOL	DM6LQGO	Hypertension	BA00-BA04	Discontinued in Phase 1	[35]
RO-16-8714	DMOVZDY	Diabetic complication	5A2Y	Discontinued in Phase 1	[36]
SB 418790	DMGHDTB	Type-2 diabetes	5A11	Discontinued in Phase 1	[37]
BMS-210285	DMMBTU6	Type-2 diabetes	5A11	Terminated	[38]
BRL 26830A	DMGX0E1	Obesity	5B81	Terminated	[39]
BRL 37344	DMS4320	N. A.	N. A.	Terminated	[40]
H-216/44	DM904UQ	Glaucoma/ocular hypertension	9C61	Terminated	[41]
SM 11044	DMF0QMD	Asthma	CA23	Terminated	[40]
SR-58878	DMS9EJ5	Irritable bowel syndrome	DD91.0	Terminated	[42]
SR-58894A	DMQUF9I	Gastrointestinal disease	DE2Z	Terminated	[43]

5 Preclinical Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
CL-314698	DM6HADZ	Obesity	5B81	Preclinical	[13]
CP-114271	DMATUKO	Obesity	5B81	Preclinical	[13]
GCR-1087	DMFW0H9	Obesity	5B81	Preclinical	[13]
L-742791	DMK3TXY	Obesity	5B81	Preclinical	[13]
L-751250	DMOERXK	Obesity	5B81	Preclinical	[13]

25 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
(-)-Ro 363	DMH6EVM	Discovery agent	N.A.	Investigative	[44]
1-(1H-Indol-4-yloxy)-3-phenethylamino-propan-2-ol	DMSUPCD	Discovery agent	N.A.	Investigative	[45]
1-(2-allylphenoxy)-3-morpholinopropan-2-ol	DMLV0PQ	Discovery agent	N.A.	Investigative	[46]
1-(2-isopropylphenoxy)-3-morpholinopropan-2-ol	DMK209P	Discovery agent	N.A.	Investigative	[46]
Carazolol	DMEKI1J	Discovery agent	N.A.	Investigative	[47]
cicloprolol	DM27S6E	Discovery agent	N.A.	Investigative	[48]
ER-23006	DMAO6JS	Asthma	CA23	Investigative	[23]
FMP-825	DMW5V9U	Diabetic complication	5A2Y	Investigative	[42]
H87/07	DM43ODJ	Discovery agent	N.A.	Investigative	[48]
iodocyanopindolol	DMOA2J8	Discovery agent	N.A.	Investigative	[49]
L-748337	DM7CPBU	Discovery agent	N.A.	Investigative	[50]
L748328	DMEGU5J	Discovery agent	N.A.	Investigative	[50]
LK 204-545	DMLVTXM	Discovery agent	N.A.	Investigative	[48]
MystiLol	DMGJYIZ	Glaucoma/ocular hypertension	9C61	Investigative	[23]
NIHP	DMDMG1O	Discovery agent	N.A.	Investigative	[48]
prenalterol	DMV8YHQ	Discovery agent	N.A.	Investigative	[51]
SB251023	DMLZDK6	Discovery agent	N.A.	Investigative	[52]
T-0509	DMSVLXQ	Discovery agent	N.A.	Investigative	[53]
Trecadrine	DMDX0VI	Discovery agent	N.A.	Investigative	[54]
Trimetoquinol	DMK9743	Discovery agent	N.A.	Investigative	[55]
xamoterol	DMOVJP3	Discovery agent	N.A.	Investigative	[56]
zinterol	DMKETL5	Discovery agent	N.A.	Investigative	[57]
[125I]ICYP	DM3BQHO	Discovery agent	N.A.	Investigative	[58]
[3H](-)CGP 12177	DMN35BY	Discovery agent	N.A.	Investigative	[59]
[3H]CGP12177	DMZN1A3	Discovery agent	N.A.	Investigative	[40]

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