Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTN1IE2)

• DTT Name: APOB messenger RNA (APOB mRNA) DTT Info
• Gene Name: APOB

Molecule-Related Drug & Molecule List

2 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mipomersen	DMGSRN1	Familial hypercholesterolemia	5C80.00	Approved	[1]
TKM-ApoB	DM2M47Y	Hypercholesterolaemia	5C80.0	Phase 4	[2]

2 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ISIS 147483	DMNMXKC	Discovery agent	N.A.	Investigative	[3]
ISIS 147788	DM1Z5W8	Discovery agent	N.A.	Investigative	[3]

References

• [1] Design and development of antisense drugs. Expert Opin. Drug Discov. 2008 3(10):1189-1207.
• [2] Current Progress of siRNA/shRNA Therapeutics in Clinical Trials. Biotechnol J. 2011 September; 6(9): 1130-1146.
• [3] US patent application no. 7,407,943, Antisense modulation of apolipoprotein B expression.