Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTN9T81)

• DTT Name: Arachidonate 15-lipoxygenase (15-LOX) DTT Info
• Gene Name: ALOX15

Molecule-Related Drug & Molecule List

8 Patented Agent(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Imidazole derivative 10	DMI7W3K	N. A.	N. A.	Patented	[1]
Imidazole derivative 11	DMTJ0DP	N. A.	N. A.	Patented	[1]
Indole and benzimidazole derivative 1	DMS0169	N. A.	N. A.	Patented	[1]
Indolizine derivative 1	DM4GZBI	N. A.	N. A.	Patented	[2]
Isothiazolone derivative 1	DMHAJCM	N. A.	N. A.	Patented	[1]
PMID26560362-Compound-90	DM9V13U	N. A.	N. A.	Patented	[1]
Tri-substituted benzene derivative 1	DMEQ3RD	N. A.	N. A.	Patented	[1]
Triazole derivative 3	DMZR0TH	N. A.	N. A.	Patented	[1]

1 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
NSC-661755	DMDJT7U	N. A.	N. A.	Terminated	[3]

30 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
(+)-(5S,8S,10S)-20-methoxy-9,15-ene-puupehenol	DMLDQWT	Discovery agent	N.A.	Investigative	[4]
(+)-(5S,8S,10S)-20-methoxypuupehenol	DMU7BJA	Discovery agent	N.A.	Investigative	[4]
(+)-(5S,8S,9R,10S)-20-methoxypuupehenone	DMD4YPO	Discovery agent	N.A.	Investigative	[4]
(+)-3,3'-bisdemethyltanegool	DMNUWVB	Discovery agent	N.A.	Investigative	[5]
(-)-3,3'-bisdemethylpinoresinol	DMGC7F5	Discovery agent	N.A.	Investigative	[5]
(-)-pinoresinol	DM4INSG	Discovery agent	N.A.	Investigative	[5]
(2E)-3-(2-OCT-1-YN-1-YLPHENYL)ACRYLIC ACID	DMKWRFA	Discovery agent	N.A.	Investigative	[6]
2,3,4,5-Tetrabromo-6-(2,4-dibromo-phenoxy)-phenol	DMK4LTB	Discovery agent	N.A.	Investigative	[7]
3,4,6-Tribromo-2-(2,4-dibromo-phenoxy)-phenol	DMO34LJ	Discovery agent	N.A.	Investigative	[7]
3,4-Dibromo-2-(5-bromo-2-hydroxy-phenoxy)-phenol	DMXQVRD	Discovery agent	N.A.	Investigative	[7]
3,6,8-Tribromo-dibenzo[1,4]dioxin-1-ol	DMM632N	Discovery agent	N.A.	Investigative	[7]
CHLOROPUUPEHENONE	DM8B0VZ	Discovery agent	N.A.	Investigative	[4]
Dimethylnordihydroguarierate acid	DMG3WTE	Discovery agent	N.A.	Investigative	[4]
DYSIDENIN	DMIZQTX	Discovery agent	N.A.	Investigative	[3]
Halisulfate 1	DMJB87Q	Discovery agent	N.A.	Investigative	[4]
Hydrohalisulfate 1	DM0HQF6	Discovery agent	N.A.	Investigative	[4]
IGERNELLIN	DMFMY1L	Discovery agent	N.A.	Investigative	[4]
Isojaspic acid	DMHTBDN	Discovery agent	N.A.	Investigative	[8]
ISOSCOPOLETIN	DMNM2SQ	Discovery agent	N.A.	Investigative	[5]
JASPAQUINOL	DMJAEMT	Discovery agent	N.A.	Investigative	[8]
Jaspic acid	DMOF0TB	Discovery agent	N.A.	Investigative	[4]
KAEMPFEROL	DMHEMUB	Discovery agent	N.A.	Investigative	[5]
MANGOSTIN	DMYQGDV	Discovery agent	N.A.	Investigative	[3]
NSC-172033	DM9QW8N	Discovery agent	N.A.	Investigative	[3]
Polybrominated diphenyl ether derivative	DMG7K84	Discovery agent	N.A.	Investigative	[7]
PUUPEHEDIONE	DMF28IU	Discovery agent	N.A.	Investigative	[8]
PUUPEHENONE	DMF3BCK	Discovery agent	N.A.	Investigative	[8]
SCOPOLETIN	DM645FP	Discovery agent	N.A.	Investigative	[5]
SPONGIADIOXIN A	DM0GJVS	Discovery agent	N.A.	Investigative	[7]
Subersic acid	DM8BLXT	Discovery agent	N.A.	Investigative	[4]

References

• [1] 15-Lipoxygenase inhibitors: a patent review.Expert Opin Ther Pat. 2016;26(1):65-88.
• [2] Inhibitors of phospholipase A2 and their therapeutic potential: an update on patents (2012-2016).Expert Opin Ther Pat. 2017 Feb;27(2):217-225.
• [3] Discovery of platelet-type 12-human lipoxygenase selective inhibitors by high-throughput screening of structurally diverse libraries. Bioorg Med Chem. 2007 Nov 15;15(22):6900-8.
• [4] Exploring sponge-derived terpenoids for their potency and selectivity against 12-human, 15-human, and 15-soybean lipoxygenases. J Nat Prod. 2003 Feb;66(2):230-5.
• [5] Lipoxygenase inhibitory constituents of the fruits of noni (Morinda citrifolia) collected in Tahiti. J Nat Prod. 2007 May;70(5):859-62.
• [6] The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
• [7] Probing the activity differences of simple and complex brominated aryl compounds against 15-soybean, 15-human, and 12-human lipoxygenase. J Med Chem. 2004 Jul 29;47(16):4060-5.
• [8] Using enzyme assays to evaluate the structure and bioactivity of sponge-derived meroterpenes. J Nat Prod. 2009 Oct;72(10):1857-63.